https://en.formulasearchengine.com/api.php?action=feedcontributions&feedformat=atom&user=134.169.106.141formulasearchengine - User contributions [en]2026-06-01T19:13:23ZUser contributionsMediaWiki 1.43.0-wmf.28https://en.formulasearchengine.com/index.php?title=Haloacetate_dehalogenase&diff=19602Haloacetate dehalogenase2012-12-04T14:13:43Z<p>134.169.106.141: </p>
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<div>{{enzyme<br />
| Name = phosphonoacetate hydrolase<br />
| EC_number = 3.11.1.2<br />
| CAS_number = 153570-68-4<br />
| IUBMB_EC_number = 3/11/1/2<br />
| GO_code = 0047400<br />
| image = File:1ei6.png<br />
| width = <br />
| caption = Structure of phosphonoacetate hydrolase. PDB entry {{PDBe|1e16}}. Zinc ions and phosphonoformate are shown in the active site.<br />
}}<br />
In [[enzymology]], a '''phosphonoacetate hydrolase''' ({{EC number|3.11.1.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]<br />
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:phosphonoacetate + H<sub>2</sub>O <math>\rightleftharpoons</math> acetate + phosphate<br />
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[phosphonoacetate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[acetate]] and [[phosphate]].<br />
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This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on carbon-phosphorus bonds. The systematic name of this enzyme class is '''phosphonoacetate phosphonohydrolase'''. This enzyme participates in [[aminophosphonate metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[zinc]]. <br />
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==Structural studies==<br />
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The [[tertiary structure|structure]] of this enzyme, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1EI6}}, shows it adopts the [[alkaline phosphatase]] fold.<br />
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==References==<br />
{{reflist|1}}<br />
* {{cite journal | author = McGrath JW, Wisdom GB, McMullan G, Larkin MJ, Quinn JP | date = 1995 | title = The purification and properties of phosphonoacetate hydrolase, a novel carbon-phosphorus bond-cleavage enzyme from Pseudomonas fluorescens 23F | journal = Eur. J. Biochem. | volume = 234 | pages = 225&ndash;30 | pmid = 8529644 | doi = 10.1111/j.1432-1033.1995.225_c.x | issue = 1 }}<br />
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{{hydrolase-stub}}<br />
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[[Category:EC 3.11.1]]<br />
[[Category:Zinc enzymes]]<br />
[[Category:Enzymes of known structure]]</div>134.169.106.141