One-way quantum computer

2014-01-07T05:18:27Z

64.106.62.45: /* Implementations */ try to fix a link problem.

{{enzyme
| Name = holocytochrome-c synthase
| EC_number = 4.4.1.17
| CAS_number = 75139-03-6
| IUBMB_EC_number = 4/4/1/17
| GO_code = 0004408
| image =
| width =
| caption =
}}
{{Infobox protein family
| Symbol = Cyto_heme_lyase
| Name = Cytochrome c/c1 heme lyase
| image =
| width =
| caption =
| Pfam = PF01265
| Pfam_clan =
| InterPro = IPR000511
| SMART =
| PROSITE = PDOC00647
| MEROPS =
| SCOP =
| TCDB =
| OPM family =
| OPM protein =
| CAZy =
| CDD =
}}
In [[enzymology]], a '''holocytochrome-c synthase''' ({{EC number|4.4.1.17}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:holocytochrome c <math>\rightleftharpoons</math> apocytochrome c + heme

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[holocytochrome c]], and two [[product (chemistry)|products]], [[apocytochrome c]] and [[heme]].

This enzyme belongs to the family of [[lyase]]s, specifically the class of carbon-sulfur lyases. The systematic name of this enzyme class is '''holocytochrome-c apocytochrome-c-lyase (heme-forming)'''. Other names in common use include '''cytochrome c heme-lyase''', '''holocytochrome c synthetase''', and '''holocytochrome-c apocytochrome-c-lyase'''. This enzyme participates in [[porphyrin and chlorophyll metabolism]].

Cytochrome c haem-lyase (CCHL) and cytochrome Cc1 haem-lyase (CC1HL) are [[mitochondrion|mitochondrial]] [[enzyme]]s that [[catalyse]] the [[covalent]] attachment of a haem group on two [[cysteine]] residues of [[cytochrome c]] and c1. These two [[enzymes]] are functionally and [[evolution|evolutionary]] related. There are two [[conserved sequence|conserved]] regions, the first is located in the central section and the second in the C-terminal section. Both patterns contain conserved [[histidine]], [[tryptophan]] and [[acidic]] residues which could be important for the interaction of the enzymes with the [[Apoenzyme#Cofactors|apoprotein]]s and/or the haem group.<ref name="pmid1499554">{{cite journal | author = Zollner A, Rodel G, Haid A | title = Molecular cloning and characterization of the Saccharomyces cerevisiae CYT2 gene encoding cytochrome-c1-heme lyase | journal = Eur. J. Biochem. | volume = 207 | issue = 3 | pages = 1093–100 |date=August 1992 | pmid = 1499554 | doi = 10.1111/j.1432-1033.1992.tb17146.x| url = }}</ref>

==References==
{{reflist|1}}
* {{cite journal | author = Dumont ME, Ernst JF, Hampsey DM, Sherman F | year = 1987 | title = Identification and sequence of the gene encoding cytochrome c heme lyase in the yeast Saccharomyces cerevisiae | journal = EMBO J. | volume = 6 | pages = 235–41 | pmid = 3034577 | issue = 1 | pmc = 553382 }}

[[Category:EC 4.4.1]]
[[Category:Enzymes of unknown structure]]

{{InterPro content|IPR000511}}
{{enzyme-stub}}

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