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{{enzyme
| Name = glycosylphosphatidylinositol diacylglycerol-lyase
| EC_number = 4.6.1.14
| CAS_number = 129070-68-4
| IUBMB_EC_number = 4/6/1/14
| GO_code = 0047396
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''glycosylphosphatidylinositol diacylglycerol-lyase''' ({{EC number|4.6.1.14}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol <math>\rightleftharpoons</math> 6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate + 1,2-diacyl-sn-glycerol

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol]], and two [[product (chemistry)|products]], [[6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate]] and [[1,2-diacyl-sn-glycerol]].

This enzyme belongs to the family of [[lyase]]s, specifically the class of phosphorus-oxygen lyases.  The systematic name of this enzyme class is '''6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol 1,2-diacyl-sn-glycerol-lyase [6-(alpha-D-glucosaminyl)-1D-myo-inositol 1,2-cyclic phosphate-forming]'''. Other names in common use include '''(glycosyl)phosphatidylinositol-specific phospholipase C''', '''GPI-PLC''', '''GPI-specific phospholipase C''', '''VSG-lipase''', '''glycosyl inositol phospholipid anchor-hydrolyzing enzyme''', '''glycosylphosphatidylinositol-phospholipase C''', '''glycosylphosphatidylinositol-specific phospholipase C''', '''variant-surface-glycoprotein phospholipase C''', '''6-(alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol''', and '''diacylglycerol-lyase (1,2-cyclic-phosphate-forming)'''.  

==References==
{{reflist|1}}
* {{cite journal | author = Hereld D, Krakow JL, Bangs JD, Hart GW, Englund PT | date = 1986 | title = A phospholipase C from Trypanosoma brucei which selectively cleaves the glycolipid on the variant surface glycoprotein | journal = J. Biol. Chem.  | volume = 261 | pages = 13813&ndash;9  | pmid = 3759991 | issue = 29 }}
* {{cite journal | author = Carnall N, Webb H, Carrington M | date = 1997 | title = Mutagenesis study of the glycosylphosphatidylinositol phospholipase C of Trypanosoma brucei | journal = Mol. Biochem. Parasitol.  | volume = 90 | pages = 423&ndash;32  | pmid = 9476790 | doi = 10.1016/S0166-6851(97)00177-1 | issue = 2 }}
* {{cite journal | author = Armah DA, Mensa-Wilmot K | date = 2000 | title = Tetramerization of glycosylphosphatidylinositol-specific phospholipase C from Trypanosoma brucei | journal = J. Biol. Chem.  | volume = 275 | pages = 19334&ndash;42  | pmid = 10764777 | doi = 10.1074/jbc.M001798200 | issue = 25 }}

{{Phosphorus-oxygen lyases}}

{{DEFAULTSORT:Glycosylphosphatidylinositol Diacylglycerol-Lyase}}
[[Category:EC 4.6.1]]
[[Category:Enzymes of unknown structure]]


{{enzyme-stub}}