View source for (3R,6E)-nerolidol synthase

{{Infobox enzyme
| Name = 5-epiaristolochene synthase
| EC_number = 4.2.3.61
| CAS_number = 
| IUBMB_EC_number = 4/2/3/61
| GO_code = 
| image = 
| width = 
| caption =
}}
'''5-epiaristolochene synthase''' ({{EC number|4.2.3.61}}, ''5-epi-aristolochene synthase'', ''tobacco epiaristolochene synthase'', ''farnesyl pyrophosphate cyclase'', ''EAS'', ''TEAS'') is an [[enzyme]] with system name ''(2E,6E)-farnesyl-diphosphate diphosphate-lyase ((+)-5-epiaristolochene-forming)''.<ref>{{cite journal | title = Expression of a plant sesquiterpene cyclase gene in ''Escherichia coli'' |author = Back, K., Yin, S. and Chappell, J. |journal = Arch. Biochem. Biophys. |year = 1994 |volume = 315 |pages = 527–532 |pmid = 7986100 |issue=2}}</ref><ref>{{cite journal | title = Structural basis for cyclic terpene biosynthesis by tobacco 5-''epi''-aristolochene synthase |author = Starks, C.M., Back, K., Chappell, J. and Noel, J.P. |journal = Science |year = 1997 |volume = 277 |pages = 1815–1820 |pmid = 9295271 |issue=5333}}</ref><ref>{{cite journal | title = Cloning and bacterial expression of sesquiterpene cyclase, a key branch point enzyme for the synthesis of sesquiterpenoid phytoalexin capsidiol in  UV-challenged leaves of ''Capsicum annuum'' |author = Back, K., He, S., Kim, K.U. and Shin, D.H. |journal = Plant Cell Physiol. |year = 1998 |volume = 39 |pages = 899–904 |pmid = 9816674 |issue=9}}</ref><ref>{{cite journal | title = Demonstration of germacrene A as an intermediate in 5-''epi''-aristolochene synthase catalysis |author = Rising, K.A., Starks, C.M., Noel, J.P. and Chappell, J. |journal = J. Am. Chem. Soc. |year = 2000 |volume = 122 |pages = 1861–1866 |pmid = }}</ref><ref>{{cite journal | title = Gene expression of 5-''epi''-aristolochene synthase and formation of capsidiol in roots of ''Nicotiana attenuata'' and ''N. <em>sylvestris''</em> |author = Bohlmann, J., Stauber, E.J., Krock, B., Oldham, N.J., Gershenzon, J. and Baldwin, I.T. |journal = Phytochemistry |year = 2002 |volume = 60 |pages = 109–116 |pmid = 12009313 |issue=2}}</ref><ref>{{cite journal | title = Biosynthetic potential of sesquiterpene synthases: alternative products of tobacco 5-''epi''-aristolochene synthase |author = O'Maille, P.E., Chappell, J. and Noel, J.P. |journal = Arch. Biochem. Biophys. |year = 2006 |volume = 448 |pages = 73–82 |pmid = 16375847 |doi=10.1016/j.abb.2005.10.028}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (2E,6E)-farnesyl diphosphate <math>\rightleftharpoons</math> (+)-5-epiaristolochene + [[diphosphate]]

Initial cyclization gives (+)-germacrene A in an enzyme bound form.

== References ==
{{reflist}}

== External links ==
*{{MeshName|5-epiaristolochene+synthase}}

[[Category:EC 4.2.3]]