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{{enzyme
| Name = adenylyl-sulfate reductase (thioredoxin)
| EC_number = 1.8.4.10
| CAS_number = 
| IUBMB_EC_number = 1/8/4/10
| GO_code = 0043866
| image = 
| width = 
| caption = 
}}
'''Adenylyl-sulfate reductase (thioredoxin)''' ({{EC number|1.8.4.10}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:AMP + sulfite + thioredoxin disulfide <math>\rightleftharpoons</math> 5'-adenylyl sulfate + thioredoxin

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine monophosphate]], [[sulfite]], and [[thioredoxin disulfide]], whereas its two [[product (chemistry)|products]] are [[5'-adenylyl sulfate]] and [[thioredoxin]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on a sulfur group of donors with a disulfide as acceptor.  The systematic name of this enzyme class is '''AMP,sulfite:thioredoxin-disulfide oxidoreductase (adenosine-5'-phosphosulfate-forming)'''. This enzyme is also called '''thioredoxin-dependent 5'-adenylylsulfate reductase'''.  

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2GOY}}.

==References==
{{reflist|1}}
* {{cite journal | author = Bick JA, Dennis JJ, Zylstra GJ, Nowack J, Leustek T | date = 2000 | title = Identification of a New Class of 5′-Adenylylsulfate (APS) Reductases from Sulfate-Assimilating Bacteria | journal = J. Bacteriol.  | volume = 182 | pages = 135&ndash;42  | pmid = 10613872 | doi = 10.1128/JB.182.1.135-142.2000 | issue = 1 | pmc = 94249 }}
* {{cite journal | author = Abola AP, Willits MG, Wang RC, Long SR | date = 1999 | title = Reduction of Adenosine-5′-Phosphosulfate Instead of 3′-Phosphoadenosine-5′-Phosphosulfate in Cysteine Biosynthesis by Rhizobium meliloti and Other Members of the Family Rhizobiaceae | journal = J. Bacteriol.  | volume = 181 | pages = 5280&ndash;7  | pmid = 10464198 | issue = 17 | pmc = 94033 }}
* {{cite journal | author = Williams SJ, Senaratne RH, Mougous JD, Riley LW, Bertozzi CR | date = 2002 | title = 5'-adenosinephosphosulfate lies at a metabolic branch point in mycobacteria | journal = J. Biol. Chem.  | volume = 277 | pages = 32606&ndash;15  | pmid = 12072441 | doi = 10.1074/jbc.M204613200 | issue = 36 }}
* {{cite journal | author = Neumann S, Wynen A, Truper HG, Dahl C | date = 2000 | title = Characterization of the cys gene locus from Allochromatium vinosum indicates an unusual sulfate assimilation pathway | journal = Mol. Biol. Rep.  | volume = 27 | pages = 27&ndash;33  | pmid = 10939523 | doi = 10.1023/A:1007058421714 | issue = 1 }}

[[Category:EC 1.8.4]]
[[Category:Enzymes of known structure]]