View source for 3-hydroxy-3-isohexenylglutaryl-CoA lyase

{{enzyme
| Name = 4-hydroxy-4-methyl-2-oxoglutarate aldolase
| EC_number = 4.1.3.17
| CAS_number = 37290-65-6
| IUBMB_EC_number = 4/1/3/17
| GO_code = 0047443
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''4-hydroxy-4-methyl-2-oxoglutarate aldolase''' ({{EC number|4.1.3.17}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:4-hydroxy-4-methyl-2-oxoglutarate <math>\rightleftharpoons</math> 2 pyruvate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[4-hydroxy-4-methyl-2-oxoglutarate]], and one [[product (chemistry)|product]], [[pyruvate]].

This enzyme belongs to the family of [[lyase]]s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds.  The systematic name of this enzyme class is '''4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase (pyruvate-forming)'''. Other names in common use include '''pyruvate aldolase''', '''gamma-methyl-gamma-hydroxy-alpha-ketoglutaric aldolase''', '''4-hydroxy-4-methyl-2-ketoglutarate aldolase''', and '''4-hydroxy-4-methyl-2-oxoglutarate pyruvate-lyase'''.  This enzyme participates in [[benzoate degradation via hydroxylation]] and [[c5-branched dibasic acid metabolism]].  

==References==
{{reflist|1}}
* {{cite journal | author = Maruyama K | date = Tokyo | title = Purification and properties of 2-pyrone-4,6-dicarboxylate hydrolase | journal = J.  | volume = Biochem. | pages = 557&ndash;65  | pmid = 6841353 | issue = 2 }}
* {{cite journal | author = Sharma ML, Kaul SM and Shukla OP | date = 1984 | title = Metabolism of 2-hydroxypyridine by Bacillus brevis (INA) | journal = Biol. Membr.  | volume = 9 | pages = 43&ndash;52 }}
* {{cite journal | author = Tack BF, Chapman PJ, Dagley S | date = 1972 | title = Purification and properties of 4-hydroxy-4-methyl-2-oxoglutarate aldolase | journal = J. Biol. Chem.  | volume = 247 | pages = 6444&ndash;9  | pmid = 5076765 | issue = 20 }}
* Boyer, P.D. (Ed.), The Enzymes, 3rd ed., vol. 7, Academic Press, New York, 1972, p. 281-302.

{{4.1-enzyme-stub}}

[[Category:EC 4.1.3]]
[[Category:Enzymes of unknown structure]]