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{{Infobox enzyme
| Name = (S)-2-hydroxypropylphosphonic acid epoxidase
| EC_number = 1.14.19.7
| CAS_number = 
| IUBMB_EC_number = 1/14/19/7
| GO_code = 
| image = 
| width = 
| caption =
}}
'''(S)-2-hydroxypropylphosphonic acid epoxidase''' ({{EC number|1.14.19.7}}, ''HPP epoxidase'', ''HppE'', ''2-hydroxypropylphosphonic acid epoxidase'', ''Fom4'', ''(S)-2-hydroxypropylphosphonate epoxidase'') is an [[enzyme]] with system name ''(S)-2-hydroxypropylphosphonate,NADH:oxygen epoxidase''.<ref>{{cite journal | title = Purification and characterization of the epoxidase catalyzing the formation of fosfomycin from ''Pseudomonas syringae'' |author = Munos, J.W., Moon, S.J., Mansoorabadi, S.O., Chang, W., Hong, L., Yan, F., Liu, A. and Liu, H.W. |journal = Biochemistry |year = 2008 |volume = 47 |pages = 8726–8735 |pmid = 18656958 |doi=10.1021/bi800877v |issue=33 |pmc=2780581}}</ref><ref>{{cite journal | title = Determination of the substrate binding mode to the active site iron of (''S'')-2-hydroxypropylphosphonic acid epoxidase using <sup>17</sup>O-enriched substrates and substrate analogues |author = Yan, F., Moon, S.J., Liu, P., Zhao, Z., Lipscomb, J.D., Liu, A. and Liu, H.W. |journal = Biochemistry |year = 2007 |volume = 46 |pages = 12628–12638 |pmid = 17927218 |doi=10.1021/bi701370e |issue=44 |pmc=2780580}}</ref><ref>{{cite journal | title = Cloning and nucleotide sequence of fosfomycin biosynthetic genes of ''Streptomyces wedmorensis'' |author = Hidaka, T., Goda, M., Kuzuyama, T., Takei, N., Hidaka, M. and Seto, H. |journal = Mol. Gen. Genet. |year = 1995 |volume = 249 |pages = 274–280 |pmid = 7500951 |issue=3}}</ref><ref>{{cite journal | title = Oxygenase activity in the self-hydroxylation of (''S'')-2-hydroxypropylphosphonic acid epoxidase involved in fosfomycin  biosynthesis |author = Liu, P., Mehn, M.P., Yan, F., Zhao, Z., Que, L., Jr. and Liu, H.W. |journal = J. Am. Chem. Soc. |year = 2004 |volume = 126 |pages = 10306–10312 |pmid = 15315444 |doi=10.1021/ja0475050 |issue=33}}</ref><ref>{{cite journal | title = Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme |author = Higgins, L.J., Yan, F., Liu, P., Liu, H.W. and Drennan, C.L. |journal = Nature |year = 2005 |volume = 437 |pages = 838–844 |pmid = 16015285 |doi=10.1038/nature03924 |issue=7060}}</ref><ref>{{cite journal | title = Initiating a crystallographic analysis of recombinant (''S'')-2-hydroxypropylphosphonic acid epoxidase from ''Streptomyces'' wedmorensis |author = Cameron, S., McLuskey, K., Chamberlayne, R., Hallyburton, I. and Hunter, W.N. |journal = Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. |year = 2005 |volume = 61 |pages = 534–536 |pmid = 16511089 |doi=10.1107/S1744309105012376 |issue=Pt 5 |pmc=1952317}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (S)-2-hydroxypropylphosphonate + NADH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> (1R,2S)-epoxypropylphosphonate + NAD<sup>+</sup> + 2 H<sub>2</sub>O

(S)-2-hydroxypropylphosphonic acid epoxidase contains one non-[[heme]] [[iron]] centre per monomer.

== References ==
{{reflist}}

== External links ==
* {{MeshName|(S)-2-hydroxypropylphosphonic+acid+epoxidase}}

[[Category:EC 1.14.19]]