View source for Coenzyme gamma-F420-2:alpha-L-glutamate ligase

{{Infobox enzyme
| Name = Cobyrinate a,c-diamide synthase
| EC_number = 6.3.5.11
| CAS_number = 
| IUBMB_EC_number = 6/3/5/11
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Cobyrinate a,c-diamide synthase''' ({{EC number|6.3.5.11}}, ''cobyrinic acid a,c-diamide synthetase'', ''CbiA (gene)'') is an [[enzyme]].<ref>{{cite journal | title = Mechanism of cobyrinic acid <em>a</em>,<em>c</em>-diamide synthetase from <em>Salmonella typhimurium</em> LT2 |author = Fresquet, V., Williams, L. and Raushel, F.M. |journal = Biochemistry |year = 2004 |volume = 43 |pages = 10619–10627 |pmid = 15311923}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 2 ATP + [[cobyrinate]] + 2 L-[[glutamine]] + 2 H<sub>2</sub>O <math>\rightleftharpoons</math> 2 ADP + 2 [[phosphate]] + cobyrinate a,c-diamide + 2 L-glutamate (overall reaction)
:(1a) ATP + cobyrinate + L-glutamine + H<sub>2</sub>O <math>\rightleftharpoons</math> ADP + phosphate + cobyrinate c-monamide + L-glutamate
:(1b) ATP + cobyrinate c-monamide + L-glutamine + H<sub>2</sub>O <math>\rightleftharpoons</math> ADP + phosphate + cobyrinate a,c-diamide + L-glutamate

This enzyme is the first glutamine amidotransferase that participates in the anaerobic biosynthetic pathway of adenosylcobalamin.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Cobyrinate+a,c-diamide+synthase}}

[[Category:EC 6.3.5]]