View source for Dimethylglycine N-methyltransferase

{{Infobox enzyme
| Name = 23S rRNA (guanine<sup>2445</sup>-N<sup>2</sup>)-methyltransferase
| EC_number = 2.1.1.173
| CAS_number = 
| IUBMB_EC_number = 2/1/1/173
| GO_code = 
| image = 
| width = 
| caption =
}}
'''23S rRNA (guanine<sup>2445</sup>-N<sup>2</sup>)-methyltransferase''' ({{EC number|2.1.1.173}}, ''ycbY (gene)'', ''rlmL (gene)'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:23S rRNA (guanine<sup>2445</sup>-N<sup>2</sup>)-methyltransferase''.<ref>{{cite journal | title = Identification of ''Escherichia coli'' m<sup>2</sup>G methyltransferases: I. the ''ycbY'' gene encodes a methyltransferase specific for G2445 of the 23 S rRNA |author = Lesnyak, D.V., Sergiev, P.V., Bogdanov, A.A. and Dontsova, O.A. |journal = J. Mol. Biol. |year = 2006 |volume = 364 |pages = 20–25 |pmid = 17010378}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[guanine]]<sup>2445</sup> in 23S rRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + N<sup>2</sup>-methylguanine<sup>2445</sup> in 23S rRNA

The enzyme methylates [[Ribosomal RNA|23S rRNA]] [[in vitro]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|23S+rRNA+(guanine2445-N2)-methyltransferase}}

[[Category:EC 2.1.1]]