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{{enzyme
| Name = ferredoxin—nitrite reductase
| EC_number = 1.7.7.1
| CAS_number = 37256-44-3
| IUBMB_EC_number = 1/7/7/1
| GO_code = 0048307
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''ferredoxin—nitrite reductase''' ({{EC number|1.7.7.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:NH<sub>3</sub> + 2 H<sub>2</sub>O + 6 oxidized [[ferredoxin]] <math>\rightleftharpoons</math> nitrite + 6 reduced ferredoxin + 7 H<sup>+</sup>

The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[ammonia|NH<sub>3</sub>]], [[water|H<sub>2</sub>O]], and [[oxidized ferredoxin]], whereas its 3 [[product (chemistry)|products]] are [[nitrite]], [[reduced ferredoxin]], and [[hydrogen ion|H<sup>+</sup>]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on other nitrogenous compounds as donors with an iron-sulfur protein as acceptor.  The systematic name of this enzyme class is '''ammonia:ferredoxin oxidoreductase'''. This enzyme participates in [[nitrogen metabolism]] and [[nitrogen assimilation]].  It has 3 [[cofactor (biochemistry)|cofactors]]: [[iron]], [[Siroheme]],  and [[Iron-sulfur]].

This enzyme can use many different isoforms of ferredoxin. In photosynthesizing tissues, it uses ferredoxin that is reduced by [[photosystem I|PSI]] and in the root it uses a form of ferredoxin (FdIII) that has a less negetive midpoint potential and can be reduced easily by NADPH.<ref name=Hanke2003>{{cite doi|10.1104/pp.103.032755}}</ref>

==Structural studies==

As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1ZJ8}}, {{PDB link|1ZJ9}}, and {{PDB link|2AKJ}}.

==References==
{{reflist|1}}
* {{cite journal | author = Joy KW, Hageman RH | year = 1966 | title = The purification and properties of nitrite reductase from higher plants, and its dependence on ferredoxin | journal = Biochem. J.  | volume = 100 | pages = 263&ndash;73  | pmid = 4381617 | issue = 1 | pmc = 1265119 }}
* {{cite journal | author = Ramirez JM, Del Campo FF, Paneque A, Losada M | year = 1966 | title = Ferredoxin-nitrite reductase from spinach | journal = Biochim. Biophys. Acta.  | volume = 118 | pages = 58&ndash;71  | pmid = 5954064 | issue = 1 }}
* {{cite journal | author = Zumft WG, Paneque A, Aparicio PJ, Losada M | year = 1969 | title = Mechanism of nitrate reduction in Chlorella | journal = Biochem. Biophys. Res. Commun.  | volume = 36 | pages = 980&ndash;6  | pmid = 4390523 | doi = 10.1016/0006-291X(69)90300-3 | issue = 6 }}

{{DEFAULTSORT:Ferredoxin-nitrite reductase}}
[[Category:EC 1.7.7]]
[[Category:Iron enzymes]]
[[Category:Siroheme enzymes]]
[[Category:Iron-sulfur enzymes]]
[[Category:Enzymes of known structure]]


{{1.7-enzyme-stub}}