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{{Infobox enzyme
| Name = Aphidicolan-16beta-ol synthase
| EC_number = 4.2.3.42
| CAS_number = 
| IUBMB_EC_number = 4/2/3/42
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Aphidicolan-16beta-ol synthase''' ({{EC number|4.2.3.42}}, ''PbACS'') is an [[enzyme]] with system name ''9alpha-copalyl-diphosphate diphosphate-lyase (aphidicolan-16beta-ol-forming)''.<ref>{{cite journal | title = Cloning and functional expression of cDNA encoding aphidicolan-16 &beta;-ol synthase: a key enzyme responsible for formation of an unusual diterpene  skeleton in biosynthesis of aphidicolin |author = Oikawa, H., Toyomasu, T., Toshima, H., Ohashi, S., Kawaide, H., Kamiya, Y., Ohtsuka, M., Shinoda, S., Mitsuhashi, W. and Sassa, T. |journal = J. Am. Chem. Soc. |year = 2001 |volume = 123 |pages = 5154–5155 |pmid = 11457369}}</ref><ref>{{cite journal | title = Cloning of a gene cluster responsible for the biosynthesis of diterpene aphidicolin, a specific inhibitor of DNA polymerase &alpha; |author = Toyomasu, T., Nakaminami, K., Toshima, H., Mie, T., Watanabe, K., Ito, H., Matsui, H., Mitsuhashi, W., Sassa, T. and Oikawa, H. |journal = Biosci. Biotechnol. Biochem. |year = 2004 |volume = 68 |pages = 146–152 |pmid = 14745177}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 9alpha-copalyl diphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> aphidicolan-16beta-ol + [[diphosphate]]

This is a bifunctional enzyme, which also has [[EC 5.5.1.14]] activity. 

== References ==
{{reflist}}

== External links ==
* {{MeshName|Aphidicolan-16beta-ol+synthase}}

[[Category:EC 4.2.3]]