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{{enzyme
| Name = isochorismate synthase
| EC_number = 5.4.4.2
| CAS_number = 37318-53-9
| IUBMB_EC_number = 5/4/4/2
| GO_code = 0008909
| image = 
| width = 
| caption = 
}}
In [[enzymology]], an '''isochorismate synthase''' ({{EC number|5.4.4.2}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:chorismate <math>\rightleftharpoons</math> isochorismate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[chorismate]], and one [[product (chemistry)|product]], [[isochorismate]].

This enzyme belongs to the family of [[isomerase]]s, specifically those intramolecular [[transferase]]s transferring hydroxy groups.  The systematic name of this enzyme class is '''isochorismate hydroxymutase'''. This enzyme participates in 2 [[metabolism|metabolic pathways]]: [[ubiquinone biosynthesis]] and [[biosynthesis of siderophore group]].  In the model plant [[Arabidopsis thaliana]], isochorismate synthase is required for salicylic acid synthesis, which occurs mainly through the chorismate-isochorismate pathway (see Wildermuth 2006 for details). 

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|2EUA}}.

==References==
{{reflist|1}}
* {{cite journal | author = Young IG, Gibson F | date = 1969 | title = Regulation of the enzymes involved in the biosynthesis of 2,3-dihydroxybenzoic acid in Aerobacter aerogenes and Escherichia coli | journal = Biochim. Biophys. Acta.  | volume = 177 | pages = 401&ndash;11  | pmid = 4306838 | issue = 3 }}
* {{cite journal | author = van Tegelen LJ, Moreno PR, Croes AF, Verpoorte R, Wullems GJ | date = 1999 | title = Purification and cDNA cloning of isochorismate synthase from elicited cell cultures of Catharanthus roseus | journal = Plant. Physiol.  | volume = 119 | pages = 705&ndash;12  | pmid = 9952467 | doi = 10.1104/pp.119.2.705 | issue = 2 | pmc = 32148 }}
* {{cite journal | author = Dahm C, Muller R, Schulte G, Schmidt K, Leistner E | date = 1998 | title = The role of isochorismate hydroxymutase genes entC and menF in enterobactin and menaquinone biosynthesis in Escherichia coli | journal = Biochim. Biophys. Acta.  | volume = 1425 | pages = 377&ndash;86  | pmid = 9795253 | issue = 2 }}

{{isomerase-stub}}

[[Category:EC 5.4.4]]
[[Category:Enzymes of known structure]]