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{{enzyme
| Name = hydroxylamine oxidase
| EC_number = 1.7.3.4
| CAS_number = 9075-43-8
| IUBMB_EC_number = 1/7/3/4
| GO_code = 0047991
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''hydroxylamine oxidase''' ({{EC number|1.7.3.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:hydroxylamine + O<sub>2</sub> <math>\rightleftharpoons</math> nitrite + H<sub>2</sub>O

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[hydroxylamine]] and [[oxygen|O<sub>2</sub>]], whereas its two [[product (chemistry)|products]] are [[nitrite]] and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on other nitrogenous compounds as donors with oxygen as acceptor.  The systematic name of this enzyme class is '''hydroxylamine:oxygen oxidoreductase'''. Other names in common use include '''HAO''' and '''hydroxylamine oxidoreductase'''.  This enzyme participates in [[nitrogen metabolism]].  It employs one [[cofactor (biochemistry)|cofactor]], [[heme]].  

==Structural studies==

As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1FGJ}}.

==References==
{{reflist|1}}
* {{cite journal | author = Hooper AB, Balny C | date = 1982 | title = Reaction of oxygen with hydroxylamine oxidoreductase of Nitrosomonas: fast kinetics | journal = FEBS. Lett.  | volume = 144 | pages = 299&ndash;303  | pmid = 7117545 | doi = 10.1016/0014-5793(82)80658-3 | issue = 2 }}
* {{cite journal | author = Lipscomb JD, Hooper AB | date = 1982 | title = Resolution of multiple heme centers of hydroxylamine oxidoreductase from Nitrosomonas. 1. Electron paramagnetic resonance spectroscopy | journal = Biochemistry.  | volume = 21 | pages = 3965&ndash;72  | pmid = 6289867 | doi = 10.1021/bi00260a010 | issue = 17 }}
* {{cite journal | author = Rees MK | date = 1968 | title = Studies of the hydroxylamine metabolism of Nitrosomonas europaea. I Purification of hydroxylamine oxidase | journal = Biochemistry.  | volume = 7 | pages = 353&ndash;66  | pmid = 5758552 | doi = 10.1021/bi00841a045 | issue = 1 }}

{{1.7-enzyme-stub}}

[[Category:EC 1.7.3]]
[[Category:Heme enzymes]]
[[Category:Enzymes of known structure]]