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{{Infobox enzyme
| Name = Formate dehydrogenase (acceptor)
| EC_number = 1.1.99.33
| CAS_number = 
| IUBMB_EC_number = 1/1/99/33
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Formate dehydrogenase (acceptor)''' ({{EC number|1.1.99.33}}, ''FDHH'', ''FDH-H'', ''FDH-O'', ''formate dehydrogenase H'', ''formate dehydrogenase O'') is an [[enzyme]] with system name ''formate:acceptor oxidoreductase''.<ref>{{cite journal | title = <em>Escherichia coli</em> formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component |author = Axley, M.J., Grahame, D.A. and Stadtman, T.C. |journal = J. Biol. Chem. |year = 1990 |volume = 265 |pages = 18213–18218 |pmid = 2211698 |issue=30}}</ref><ref>{{cite journal | title = Characterization of crystalline formate dehydrogenase H from <em>Escherichia coli</em>. Stabilization, EPR spectroscopy, and preliminary crystallographic  analysis |author = Gladyshev, V.N., Boyington, J.C., Khangulov, S.V., Grahame, D.A., Stadtman, T.C. and Sun, P.D. |journal = J. Biol. Chem. |year = 1996 |volume = 271 |pages = 8095–8100 |pmid = 8626495 |issue=14}}</ref><ref>{{cite journal | title = Selenium-containing formate dehydrogenase H from <em>Escherichia coli</em>: a molybdopterin enzyme that catalyzes formate oxidation without oxygen  transfer |author = Khangulov, S.V., Gladyshev, V.N., Dismukes, G.C. and Stadtman, T.C. |journal = Biochemistry |year = 1998 |volume = 37 |pages = 3518–3528 |pmid = 9521673 |doi=10.1021/bi972177k}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: formate + acceptor <math>\rightleftharpoons</math> CO<sub>2</sub> + reduced acceptor

Formate dehydrogenase H is a cytoplasmic enzyme that oxidizes [[formate]] without [[oxygen]] transfer] transferring electrons to a [[hydrogenase]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Formate+dehydrogenase+(acceptor)}}

[[Category:EC 1.1.99]]