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{{Infobox enzyme
| Name = NAD(P)H-hydrate epimerase
| EC_number = 5.1.99.6
| CAS_number = 
| IUBMB_EC_number = 5/1/99/6
| GO_code = 
| image = 
| width = 
| caption =
}}
'''NAD(P)H-hydrate epimerase''' ({{EC number|5.1.99.6}}, ''NAD(P)HX epimerase'') is an [[enzyme]] with system name ''(6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide 6-epimerase''.<ref>{{cite journal | title = Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair |author = Marbaix, A.Y., Noel, G., Detroux, A.M., Vertommen, D., Van Schaftingen, E. and Linster, C.L. |journal = J. Biol. Chem. |date = 2011 |volume = 286 |pages = 41246-41252 |pmid = 21994945}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

:(1) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide <math>\rightleftharpoons</math> (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide
:(2) (6R)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate <math>\rightleftharpoons</math> (6S)-6beta-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate 

The enzyme can use either (R)-NADH-hydrate or (R)-NADPH-hydrate as a substrate.

== References ==
{{reflist}}

== External links ==
* {{MeshName|NAD(P)H-hydrate+epimerase}}

[[Category:EC 5.1.99]]