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{{enzyme
| Name = Inositol-pentakisphosphate 2-kinase
| EC_number = 2.7.1.158
| CAS_number = 
| IUBMB_EC_number = 2/7/1/158
| GO_code = 
| image = 
| width = 
| caption = 
}}

In [[enzymology]], an '''inositol-pentakisphosphate 2-kinase''' ({{EC number|2.7.1.158}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate <math>\rightleftharpoons</math> ADP + 1D-myo-inositol hexakisphosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[1D-myo-inositol 1,3,4,5,6-pentakisphosphate]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[1D-myo-inositol hexakisphosphate]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor.  The systematic name of this enzyme class is '''ATP:1D-myo-inositol 1,3,4,5,6-pentakisphosphate 2-phosphotransferase'''. Other names in common use include '''IP5 2-kinase''', '''Gsl1p''', '''Ipk1p''', '''inositol polyphosphate kinase''', '''inositol 1,3,4,5,6-pentakisphosphate 2-kinase''', and '''Ins(1,3,4,5,6)P5 2-kinase'''.  

==References==
{{reflist|1}}
* {{cite journal | author = York JD, Odom AR, Murphy R, Ives EB, Wente SR | date = 1999 | title = A phospholipase C-dependent inositol polyphosphate kinase pathway required for efficient messenger RNA export | journal = Science.  | volume = 285 | pages = 96&ndash;100  | pmid = 10390371 | doi = 10.1126/science.285.5424.96 | issue = 5424 }}
* {{cite journal | author = Phillippy BQ, Ullah AH, Ehrlich KC | date = 1994 | title = Purification and some properties of inositol 1,3,4,5,6-Pentakisphosphate 2-kinase from immature soybean seeds | journal = J. Biol. Chem.  | volume = 269 | pages = 28393&ndash;9  | pmid = 7961779 | issue = 45 }}
* {{cite journal | author = Phillippy BQ, Ullah AH and Ehrlich KC | date = 1997 | title = Additions and corrections to Purification and some properties of inositol 1,3,4,5,6-pentakisphosphate 2-kinase from immature soybean seeds | journal = J. Biol. Chem.  | volume = 270 | issue = 13 | pages = 7782 | doi = 10.1074/jbc.270.13.7782 }}
* {{cite journal | author = Ongusaha PP, Hughes PJ, Davey J, Michell RH | date =  Pt 3 | title = Inositol hexakisphosphate in Schizosaccharomyces pombe: synthesis from Ins(1,4,5)P3 and osmotic regulation | journal = Biochem. J.  | volume = 335 | pages = 671&ndash;9  | pmid = 9794810 | pmc = 1219831 }}
* {{cite journal | author = Miller AL, Suntharalingam M, Johnson SL, Audhya A, Emr SD, Wente SR | date = 2004 | title = Cytoplasmic inositol hexakisphosphate production is sufficient for mediating the Gle1-mRNA export pathway | journal = J. Biol. Chem.  | volume = 279 | pages = 51022&ndash;32  | pmid = 15459192 | doi = 10.1074/jbc.M409394200 | issue = 49 }}
* {{cite journal | author = Stevenson-Paulik J, Odom AR, York JD | date = 2002 | title = Molecular and biochemical characterization of two plant inositol polyphosphate 6-/3-/5-kinases | journal = J. Biol. Chem.  | volume = 277 | pages = 42711&ndash;8  | pmid = 12226109 | doi = 10.1074/jbc.M209112200 | issue = 45 }}

{{enzyme-stub}}

[[Category:EC 2.7.1]]
[[Category:Enzymes of unknown structure]]