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{{enzyme
| Name = N-acetylneuraminate lyase
| EC_number = 4.1.3.3
| CAS_number = 9027-60-5
| IUBMB_EC_number = 4/1/3/3
| GO_code = 0008747
| image = 
| width = 
| caption = 
}}
In [[enzymology]], a '''N-acetylneuraminate lyase''' ({{EC number|4.1.3.3}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:N-acetylneuraminate <math>\rightleftharpoons</math> N-acetyl-D-mannosamine + pyruvate

Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[N-acetylneuraminate]], and two [[product (chemistry)|products]], [[N-acetyl-D-mannosamine]] and [[pyruvate]].

This enzyme belongs to the family of [[lyase]]s, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds.  The systematic name of this enzyme class is '''N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)'''. Other names in common use include '''N-acetylneuraminic acid aldolase''', '''acetylneuraminate lyase''', '''sialic aldolase''', '''sialic acid aldolase''', '''sialate lyase''', '''N-acetylneuraminic aldolase''', '''neuraminic aldolase''', '''N-acetylneuraminate aldolase''', '''neuraminic acid aldolase''', '''N-acetylneuraminic acid aldolase''', '''neuraminate aldolase''', '''N-acetylneuraminic lyase''', '''N-acetylneuraminic acid lyase''', '''NPL''', '''NALase''', '''NANA lyase''', '''acetylneuraminate pyruvate-lyase''', and '''N-acetylneuraminate pyruvate-lyase'''.  This enzyme participates in [[aminosugars metabolism]].  

==Structural studies==

As of late 2007, 10 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1F5Z}}, {{PDB link|1F6K}}, {{PDB link|1F6P}}, {{PDB link|1F73}}, {{PDB link|1F74}}, {{PDB link|1F7B}}, {{PDB link|1FDY}}, {{PDB link|1FDZ}}, {{PDB link|1HL2}}, and {{PDB link|1NAL}}.

==References==
{{reflist|1}}
* {{cite journal | author = COMB DG, ROSEMAN S | date = 1960 | title = The sialic acids. I. The structure and enzymatic synthesis of N-acetylneuraminic acid | journal = J. Biol. Chem.  | volume = 235 | pages = 2529&ndash;37  | pmid = 13811398 }}
* {{cite journal | author = Schauer R | date = 1982 | title = Advances in Carbohydrate Chemistry and Biochemistry Volume 40 | journal = Adv. Carbohydr. Chem. Biochem.  | volume = 40 | pages = 131&ndash;234  | pmid = 6762816 | doi = 10.1016/S0065-2318(08)60109-2 | chapter = Chemistry, Metabolism, and Biological Functions of Sialic Acids | series = Advances in Carbohydrate Chemistry and Biochemistry | isbn = 978-0-12-007240-8 }}

{{4.1-enzyme-stub}}

[[Category:EC 4.1.3]]
[[Category:Enzymes of known structure]]