View source for Limonene 1,2-monooxygenase

{{Infobox enzyme
| Name = 5-epiaristolochene 1,3-dihydroxylase
| EC_number = 1.14.13.119
| CAS_number = 
| IUBMB_EC_number = 1/14/13/119
| GO_code = 
| image = 
| width = 
| caption =
}}
'''5-epiaristolochene 1,3-dihydroxylase''' ({{EC number|1.14.13.119}}, ''5-epi-aristolochene 1,3-dihydroxylase'', ''EAH'') is an [[enzyme]] with system name ''5-epiaristolochene,NADPH:oxygen oxidoreductase (1- and 3-hydroxylating)''.<ref>{{cite journal | title = Cloning, heterologous expression, and functional characterization of 5-''epi''-aristolochene-1,3-dihydroxylase from tobacco (''Nicotiana tabacum'') |author = Ralston, L., Kwon, S.T., Schoenbeck, M., Ralston, J., Schenk, D.J., Coates, R.M. and Chappell, J. |journal = Arch. Biochem. Biophys. |year = 2001 |volume = 393 |pages = 222–235 |pmid = 11556809 |doi=10.1006/abbi.2001.2483 |issue=2}}</ref><ref>{{cite journal | title = Kinetic and molecular analysis of 5-epiaristolochene 1,3-dihydroxylase, a cytochrome ''P''<sub>450</sub> enzyme catalyzing successive hydroxylations of  sesquiterpenes |author = Takahashi, S., Zhao, Y., O'Maille, P.E., Greenhagen, B.T., Noel, J.P., Coates, R.M. and Chappell, J. |journal = J. Biol. Chem. |year = 2005 |volume = 280 |pages = 3686–3696 |pmid = 15522862 |doi=10.1074/jbc.M411870200 |issue=5 |pmc=2859954}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: 5-epiaristolochene + 2 NADPH + 2 H<sup>+</sup> + 2 O<sub>2</sub> <math>\rightleftharpoons</math> capsidiol + 2 NADP<sup>+</sup> + 2 H<sub>2</sub>O

5-epiaristolochene 1,3-dihydroxylase is a [[heme]]-[[thiol]]ate protein (P-450).

== References ==
{{reflist}}

== External links ==
* {{MeshName|5-epiaristolochene+1,3-dihydroxylase}}

[[Category:EC 1.14.13]]