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{{Infobox enzyme
| Name = Crotonyl-CoA carboxylase/reductase
| EC_number = 1.3.1.85
| CAS_number = 
| IUBMB_EC_number = 1/3/1/85
| GO_code = 
| image = 
| width = 
| caption =
}}
'''Crotonyl-CoA carboxylase/reductase''' ({{EC number|1.3.1.85}}, ''CCR'', ''crotonyl-CoA reductase (carboxylating)'') is an [[enzyme]] with system name ''(2S)-ethylmalonyl-CoA:NADP<sup>+</sup> oxidoreductase (decarboxylating)''.<ref>{{cite journal | title = Synthesis of C<sub>5</sub>-dicarboxylic acids from C<sub>2</sub>-units involving crotonyl-CoA carboxylase/reductase: the ethylmalonyl-CoA pathway |author = Erb, T.J., Berg, I.A., Brecht, V., Muller, M., Fuchs, G. and Alber, B.E. |journal = Proc. Natl. Acad. Sci. USA |year = 2007 |volume = 104 |pages = 10631–10636 |pmid = 17548827 |doi=10.1073/pnas.0702791104 |pmc=1965564}}</ref><ref>{{cite journal | title = Carboxylation mechanism and stereochemistry of crotonyl-CoA carboxylase/reductase, a carboxylating enoyl-thioester reductase |author = Erb, T.J., Brecht, V., Fuchs, G., Muller, M. and Alber, B.E. |journal = Proc. Natl. Acad. Sci. USA |year = 2009 |volume = 106 |pages = 8871–8876 |pmid = 19458256 |doi=10.1073/pnas.0903939106 |pmc=2689996}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (2S)-ethylmalonyl-CoA + NADP<sup>+</sup> <math>\rightleftharpoons</math> (E)-but-2-enoyl-CoA + CO<sub>2</sub> + NADPH + H<sup>+</sup>

The reaction is catalysed in the reverse direction.

== References ==
{{reflist}}

== External links ==
* {{MeshName|Crotonyl-CoA+carboxylase/reductase}}

{{DEFAULTSORT:Crotonyl-CoA carboxylase reductase}}
[[Category:EC 1.3.1]]