View source for TRNA (guanine26-N2/guanine27-N2)-dimethyltransferase

{{Infobox enzyme
| Name = 16S rRNA (cytidine<sup>1409</sup>-2'-O)-methyltransferase
| EC_number = 2.1.1.227
| CAS_number = 
| IUBMB_EC_number = 2/1/1/227
| GO_code = 
| image = 
| width = 
| caption =
}}
'''16S rRNA (cytidine<sup>1409</sup>-2'-O)-methyltransferase''' ({{EC number|2.1.1.227}}, ''TlyA'') is an [[enzyme]] with system name ''S-adenosyl-L-methionine:16S rRNA (cytidine<sup>1409</sup>-2'-O)-methyltransferase''.<ref>{{cite journal | title = Capreomycin binds across the ribosomal subunit interface using <em>tlyA</em>-encoded 2&prime;-<em>O</em>-methylations in 16S and 23S rRNAs |author = Johansen, S.K., Maus, C.E., Plikaytis, B.B. and Douthwaite, S. |journal = Mol. Cell |year = 2006 |volume = 23 |pages = 173–182 |pmid = 16857584 |doi=10.1016/j.molcel.2006.05.044}}</ref><ref>{{cite journal | title = Mutation of <em>tlyA</em> confers capreomycin resistance in <em>Mycobacterium tuberculosis</em> |author = Maus, C.E., Plikaytis, B.B. and Shinnick, T.M. |journal = Antimicrob. Agents Chemother. |year = 2005 |volume = 49 |pages = 571–577 |pmid = 15673735 |doi=10.1128/AAC.49.2.571-577.2005 |issue=2}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[S-adenosyl-L-methionine]] + [[cytidine]]<sup>1409</sup> in 16S rRNA <math>\rightleftharpoons</math> [[S-adenosyl-L-homocysteine]] + 2'-O-methylcytidine1<sup>409</sup> in 16S rRNA

The bifunctional enzyme from [[Mycobacterium tuberculosis]]. 

== References ==
{{reflist}}

== External links ==
* {{MeshName|16S+rRNA+(cytidine1409-2'-O)-methyltransferase}}

[[Category:EC 2.1.1]]