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{{enzyme
| Name = UDP-glucose:hexose-1-phosphate uridylyltransferase
| EC_number = 2.7.7.12
| CAS_number = 9026-21-5
| IUBMB_EC_number = 2/7/7/12
| GO_code = 0008108
| image = 
| width = 
| caption = 
}}
{{Orphan|date=February 2009}}
In [[enzymology]], an '''UDP-glucose—hexose-1-phosphate uridylyltransferase''' ({{EC number|2.7.7.12}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:UDP-glucose + alpha-D-galactose 1-phosphate <math>\rightleftharpoons</math> alpha-D-glucose 1-phosphate + UDP-galactose

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[UDP-glucose]] and [[alpha-D-galactose 1-phosphate]], whereas its two [[product (chemistry)|products]] are [[alpha-D-glucose 1-phosphate]] and [[UDP-galactose]].

This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing [[nucleotide]] groups ([[nucleotidyltransferase]]s).  The systematic name of this enzyme class is '''UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase'''. Other names in common use include '''uridyl transferase''', '''hexose-1-phosphate uridylyltransferase''', '''uridyltransferase''', and '''hexose 1-phosphate uridyltransferase'''.  This enzyme participates in [[galactose metabolism]] and [[nucleotide sugars metabolism]].

==Structural studies==

As of late 2007, 4 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1HXQ}}, {{PDB link|2H39}}, {{PDB link|2Q4H}}, and {{PDB link|2Q4L}}.

==References==
{{reflist|1}}
* {{cite journal | author = KALCKAR HM, BRAGANCA B, MUNCH-PETERSEN HM | year = 1953 | title = Uridyl transferases and the formation of uridine diphosphogalactose | journal = Nature.  | volume = 172 | pages = 1038  | pmid = 13111247 | doi = 10.1038/1721038a0 | issue = 4388 }}
* {{cite journal | author = KURAHASHI K, SUGIMURA A | year = 1960 | title = Purification and properties of galactose 1-phosphate uridyl transferase from Escherichia coli | journal = J. Biol. Chem.  | volume = 235 | pages = 940&ndash;6  | pmid = 14412847 }}
* {{cite journal | author = Mayes JS and Hansen RG | year = 1966 | title = Galactose 1-phosphate uridyl transferase | journal = Methods Enzymol.  | volume = 9 | pages = 708&ndash;713 | doi = 10.1016/0076-6879(66)09143-2 }}
* {{cite journal | author = Saito S, Ozutsumi M, Kurahashi K | year = 1967 | title = Galactose 1-phosphate uridylyltransferase of Escherichia coli. II Further purification and characterization | journal = J. Biol. Chem.  | volume = 242 | pages = 2362&ndash;8  | pmid = 5338129 | issue = 10 }}
* {{cite journal | author = SMITH EE, MILLS GT | year = 1955 | title = The uridyl transferase of mammary gland | journal = Biochim. Biophys. Acta.  | volume = 18 | pages = 152  | pmid = 13260264 | doi = 10.1016/0006-3002(55)90029-9 | issue = 1 }}

{{DEFAULTSORT:UDP-glucose-hexose-1-phosphate uridylyltransferase}}
[[Category:EC 2.7.7]]
[[Category:Enzymes of known structure]]


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