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{{Infobox enzyme
| Name = S-methyl-5'-thioinosine phosphorylase
| EC_number = 2.4.2.44
| CAS_number = 
| IUBMB_EC_number = 2/4/2/44
| GO_code = 
| image = 
| width = 
| caption =
}}
'''S-methyl-5'-thioinosine phosphorylase''' ({{EC number|2.4.2.44}}, ''MTIP'', ''MTI phosphorylase'', ''methylthioinosine phosphorylase'') is an [[enzyme]] with system name ''S-methyl-5'-thioinosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase''.<ref>{{cite journal | title = Methylthioinosine phosphorylase from ''Pseudomonas aeruginosa''. Structure and annotation of a novel enzyme in quorum sensing |author = Guan, R., Ho, M.C., Almo, S.C. and Schramm, V.L. |journal = Biochemistry |year = 2011 |volume = 50 |pages = 1247–1254 |pmid = 21197954}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: S-methyl-5'-thioinosine + [[phosphate]] <math>\rightleftharpoons</math> [[hypoxanthine]] + S-methyl-5-thio-alpha-D-ribose 1-phosphate

The [[catabolism]] of 5'-methylthioadenosine in ''[[Pseudomonas aeruginosa]]'' involves deamination to S-methyl-5'-thioinosine ([[EC 3.5.4.31]], S-methyl-5'-thioadenosine deaminase) and [[phosphorolysis]] to [[hypoxanthine]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|S-methyl-5'-thioinosine+phosphorylase}}

[[Category:EC 2.4.2]]