en>BG19bot: WP:CHECKWIKI error fix for #64. Do general fixes if a problem exists. - using AWB (9890)

2014-01-28T06:40:04Z

WP:CHECKWIKI error fix for #64. Do general fixes if a problem exists. - using AWB (9890)

New page

{{Infobox enzyme
| Name = Tryptophan 7-halogenase
| EC_number = 1.14.14.7
| CAS_number =
| IUBMB_EC_number = 1/14/14/7
| GO_code =
| image =
| width =
| caption =
}}
'''Tryptophan 7-halogenase''' ({{EC number|1.14.14.7}}, ''PrnA'', ''RebH'') is an [[enzyme]] with system name ''L-tryptophan:FADH2 oxidoreductase (7-halogenating)''.<ref>{{cite journal | title = Crystallization and X-ray diffraction of a halogenating enzyme, tryptophan 7-halogenase, from Pseudomonas fluorescens |author = Dong, C., Kotzsch, A., Dorward, M., van Pee, K.H. and Naismith, J.H. |journal = Acta Crystallogr. D Biol. Crystallogr. |year = 2004 |volume = 60 |pages = 1438–1440 |pmid = 15272170 |doi=10.1107/S0907444904012521 |issue=Pt 8}}</ref><ref>{{cite journal | title = Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis |author = Yeh, E., Garneau, S. and Walsh, C.T. |journal = Proc. Natl. Acad. Sci. USA |year = 2005 |volume = 102 |pages = 3960–3965 |pmid = 15743914 |doi=10.1073/pnas.0500755102 |issue=11 |pmc=554827}}</ref><ref>{{cite journal | title = The structure of flavin-dependent tryptophan 7-halogenase RebH |author = Bitto, E., Huang, Y., Bingman, C.A., Singh, S., Thorson, J.S. and Phillips Jr., G.N. |journal = Proteins Struct. Funct. Genet. |year = 2008 |volume = 70 |pages = 289–293 |pmid = }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: [[tryptophan]] + FADH2 + Cl- + O2 + H+ <math>\rightleftharpoons</math> 7-chloro-L-tryptophan + FAD + 2 H2O

In ''[[Lechevalieria aerocolonigenes]]'' the enzyme catalyses the initial step in the biosynthesis of [[rebeccamycin]].

== References ==
{{reflist}}

== External links ==
* {{MeshName|Tryptophan+7-halogenase}}

[[Category:EC 1.14.14]]

Acoustoelastic effect - Revision history

en>BG19bot: WP:CHECKWIKI error fix for #64. Do general fixes if a problem exists. - using AWB (9890)