https://en.formulasearchengine.com/index.php?action=history&feed=atom&title=Azimi_Q_models Azimi Q models - Revision history 2026-06-24T16:54:04Z Revision history for this page on the wiki MediaWiki 1.43.0-wmf.28 https://en.formulasearchengine.com/index.php?title=Azimi_Q_models&diff=29333&oldid=prev en>Ironholds: Added tags to the page using Page Curation (more footnotes, technical) 2013-07-16T01:40:20Z <p>Added tags to the page using <a href="https://en.wikipedia.org/wiki/Page_Curation" class="extiw" title="wikipedia:Page Curation">Page Curation</a> (more footnotes, technical)</p> <p><b>New page</b></p><div>{{Infobox enzyme<br /> | Name = UDP-N-acetylglucosamine 2-epimerase (hydrolysing)<br /> | EC_number = 3.2.1.183<br /> | CAS_number = <br /> | IUBMB_EC_number = 3/2/1/183<br /> | GO_code = <br /> | image = <br /> | width = <br /> | caption =<br /> }}<br /> &#039;&#039;&#039;UDP-N-acetylglucosamine 2-epimerase (hydrolysing)&#039;&#039;&#039; ({{EC number|3.2.1.183}}, &#039;&#039;UDP-N-acetylglucosamine 2-epimerase&#039;&#039;, &#039;&#039;GNE (gene)&#039;&#039;, &#039;&#039;siaA (gene)&#039;&#039;, &#039;&#039;neuC (gene)&#039;&#039;) is an [[enzyme]] with system name &#039;&#039;UDP-N-acetyl-alpha-D-glucosamine hydrolase (2-epimerising)&#039;&#039;.&lt;ref&gt;{{cite journal | title = A bifunctional enzyme catalyzes the first two steps in &#039;&#039;N&#039;&#039;-acetylneuraminic acid biosynthesis of rat liver. Molecular cloning and functional expression of UDP-&#039;&#039;N&#039;&#039;-acetyl-glucosamine 2-epimerase/&#039;&#039;N&#039;&#039;-acetylmannosamine kinase |author = Stasche, R., Hinderlich, S., Weise, C., Effertz, K., Lucka, L., Moormann, P. and Reutter, W. |journal = J. Biol. Chem. |year = 1997 |volume = 272 |pages = 24319–24324 |pmid = 9305888 |doi=10.1074/jbc.272.39.24319}}&lt;/ref&gt;&lt;ref&gt;{{cite journal | title = Sialic acid biosynthesis: stereochemistry and mechanism of the reaction catalyzed by the mammalian UDP-&#039;&#039;N&#039;&#039;-acetylglucosamine 2-epimerase |author = Chou, W.K., Hinderlich, S., Reutter, W. and Tanner, M.E. |journal = J. Am. Chem. Soc. |year = 2003 |volume = 125 |pages = 2455–2461 |pmid = 12603133 |doi=10.1021/ja021309g |issue=9}}&lt;/ref&gt;&lt;ref&gt;{{cite journal | title = UDP-&#039;&#039;N&#039;&#039;-acetylglucosamine 2-epimerase/&#039;&#039;N&#039;&#039;-acetylmannosamine kinase, functionally expressed in and purified from &#039;&#039;Escherichia coli&#039;&#039;, yeast, and insect cells |author = Blume, A., Ghaderi, D., Liebich, V., Hinderlich, S., Donner, P., Reutter, W. and Lucka, L. |journal = Protein Expr. Purif. |year = 2004 |volume = 35 |pages = 387–396 |pmid = 15135418 |doi=10.1016/j.pep.2004.02.013 |issue=2}}&lt;/ref&gt;&lt;ref&gt;{{cite journal | title = Identification and mechanism of a bacterial hydrolyzing UDP-&#039;&#039;N&#039;&#039;-acetylglucosamine 2-epimerase |author = Murkin, A.S., Chou, W.K., Wakarchuk, W.W. and Tanner, M.E. |journal = Biochemistry |year = 2004 |volume = 43 |pages = 14290–14298 |pmid = 15518580 |doi=10.1021/bi048606d |issue=44}}&lt;/ref&gt; This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]<br /> <br /> : UDP-N-acetyl-alpha-D-glucosamine + H&lt;sub&gt;2&lt;/sub&gt;O &lt;math&gt;\rightleftharpoons&lt;/math&gt; N-acetyl-D-mannosamine + UDP<br /> <br /> The enzyme is found in mammalian [[liver]], as well as in some [[pathogenic]] [[bacteria]] including &#039;&#039;[[Neisseria meningitidis]]&#039;&#039; and &#039;&#039;[[Staphylococcus aureus]]&#039;&#039;.<br /> <br /> == References ==<br /> {{reflist}}<br /> <br /> == External links ==<br /> * {{MeshName|UDP-N-acetylglucosamine+2-epimerase+(hydrolysing)}}<br /> <br /> [[Category:EC 3.2.1]]</div> en>Ironholds