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{{Infobox enzyme
| Name = Diacetyl reductase ((S)-acetoin forming)
| EC_number = 1.1.1.304
| CAS_number =
| IUBMB_EC_number = 1/1/1/304
| GO_code =
| image =
| width =
| caption =
}}
'''Diacetyl reductase ((S)-acetoin forming)''' ({{EC number|1.1.1.304}}, ''(S)-acetoin dehydrogenase'') is an [[enzyme]] with system name ''(S)-acetoin:NAD+ oxidoreductase''.<ref>{{cite journal | title = Properties of diacetyl (acetoin) reductase from ''Bacillus stearothermophilus'' |author = Giovannini, P.P., Medici, A., Bergamini, C.M. and Rippa, M. |journal = Bioorg. Med. Chem. |year = 1996 |volume = 4 |pages = 1197–1201 |pmid = 8879540}}</ref><ref>{{cite journal | title = Purification, characterization and some properties of diacetyl(acetoin) reductase from ''Enterobacter aerogenes'' |author = Carballo, J., Martin, R., Bernardo, A. and Gonzalez, J. |journal = Eur. J. Biochem. |year = 1991 |volume = 198 |pages = 327–332 |pmid = 2040298}}</ref><ref>{{cite journal | title = Sequence analysis of the gene for and characterization of D-acetoin forming ''meso''-2,3-butanediol dehydrogenase of ''Klebsiella pneumoniae'' expressed in ''Escherichia coli'' |author = Ui, S., Okajima, Y., Mimura, A., Kanai, H., Kobayashi, T., Kudo, T. |journal = J. Ferment. Bioeng. |year = 1997 |volume = 83 |pages = 32–37 |pmid = }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: (S)-acetoin + NAD+ <math>\rightleftharpoons</math> diacetyl + NADH + H+

The reaction is catalysed in the reverse direction. This activity is usually associated with butanediol dehydrogenase activity ([[EC 1.1.1.4]] or [[EC 1.1.1.76]]). While the butanediol dehydrogenase activity is reversible, [[diacetyl reductase]] activity is irreversible. This enzyme has been reported in the [[bacteria]] ''[[Geobacillus stearothermophilus]]'', ''[[Enterobacter aerogenes]]'' and ''[[Klebsiella pneumoniae]]''. Different from EC [[1.1.1.303]], [[diacetyl reductase ((R)-acetoin forming)]].

== References ==
{{reflist}}

[[Category:EC 1.1.1]]

Bounding point - Revision history

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