86.72.16.23: /* Propagation */

2014-01-18T16:28:25Z

Propagation

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{{Infobox enzyme
| Name = M7GpppN-mRNA hydrolase
| EC_number = 3.6.1.62
| CAS_number =
| IUBMB_EC_number = 3/6/1/62
| GO_code =
| image =
| width =
| caption =
}}
'''M7GpppN-mRNA hydrolase''' ({{EC number|3.6.1.62}}, ''[[DCP2]]'', ''NUDT16'', ''D10 protein'', ''D9 protein'', ''D10 decapping enzyme'', ''decapping enzyme'') is an [[enzyme]] with system name ''m7GpppN-mRNA m7GDP phosphohydrolase''.<ref>{{cite journal | title = Arabidopsis DCP2, DCP1, and VARICOSE form a decapping complex required for postembryonic development |author = Xu, J., Yang, J.Y., Niu, Q.W. and Chua, N.H. |journal = Plant Cell |date = 2006 |volume = 18 |pages = 3386-3398 |pmid = 17158604 |doi=10.1105/tpc.106.047605}}</ref><ref>{{cite journal | title = hNUDT16: a universal decapping enzyme for small nucleolar RNA and cytoplasmic mRNA |author = Lu, G., Zhang, J., Li, Y., Li, Z., Zhang, N., Xu, X., Wang, T., Guan, Z., Gao, G.F. and Yan, J. |journal = Protein Cell |date = 2011 |volume = 2 |pages = 64-73 |pmid = 21337011 |doi=10.1007/s13238-011-1009-2}}</ref><ref>{{cite journal | title = Human Dcp2: a catalytically active mRNA decapping enzyme located in specific cytoplasmic structures |author = van Dijk, E., Cougot, N., Meyer, S., Babajko, S., Wahle, E. and Seraphin, B. |journal = EMBO J. |date = 2002 |volume = 21 |pages = 6915-6924 |pmid = 12486012 |doi=10.1093/emboj/cdf678 |pmc=139098}}</ref><ref>{{cite journal | title = Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression |author = Parrish, S., Resch, W. and Moss, B. |journal = Proc. Natl. Acad. Sci. USA |date = 2007 |volume = 104 |pages = 2139-2144 |pmid = 17283339 |doi=10.1073/pnas.0611685104}}</ref><ref>{{cite journal | title = Characterization of the vaccinia virus D10 decapping enzyme provides evidence for a two-metal-ion mechanism |author = Souliere, M.F., Perreault, J.P. and Bisaillon, M. |journal = Biochem. J. |date = 2009 |volume = 420 |pages = 27-35 |pmid = 19210265 |doi=10.1042/BJ20082296}}</ref><ref>{{cite journal | title = Characterization of a second vaccinia virus mRNA-decapping enzyme conserved in poxviruses |author = Parrish, S. and Moss, B. |journal = J. Virol. |date = 2007 |volume = 81 |pages = 12973-12978 |pmid = 17881455 |doi=10.1128/JVI.01668-07}}</ref><ref>{{cite journal | title = Multiple mRNA decapping enzymes in mammalian cells |author = Song, M.G., Li, Y. and Kiledjian, M. |journal = Mol. Cell |date = 2010 |volume = 40 |pages = 423-432 |pmid = 21070968 |doi=10.1016/j.molcel.2010.10.010}}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]

: m7G5'ppp5'-mRNA + H2O <math>\rightleftharpoons</math> m7GDP + 5'-phospho-mRNA

Decapping of mRNA is essential in [[eukaryotic]] mRNA turnover.

== References ==
{{reflist}}

== External links ==
* {{MeshName|M7GpppN-mRNA+hydrolase}}

[[Category:EC 3.6.1]]

Interval propagation - Revision history

86.72.16.23: /* Propagation */