en>Helpful Pixie Bot: ISBNs (Build KC)

2012-05-05T23:33:32Z

ISBNs (Build KC)

New page

{{enzyme
| Name = nucleoside-diphosphatase
| EC_number = 3.6.1.6
| CAS_number = 9027-69-4
| IUBMB_EC_number = 3/6/1/6
| GO_code = 0017110
| image =
| width =
| caption =
}}
In [[enzymology]], a '''nucleoside-diphosphatase''' ({{EC number|3.6.1.6}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:a nucleoside diphosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> a nucleotide + phosphate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[nucleoside diphosphate]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[nucleotide]] and [[phosphate]].

This enzyme belongs to the family of [[hydrolase]]s, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is '''nucleoside-diphosphate phosphohydrolase'''. Other names in common use include '''thiaminpyrophosphatase''', '''UDPase''', '''inosine diphosphatase''', '''adenosine diphosphatase''', '''IDPase''', '''ADPase''', '''adenosinepyrophosphatase''', '''guanosine diphosphatase''', '''guanosine 5'-diphosphatase''', '''inosine 5'-diphosphatase''', '''uridine diphosphatase''', '''uridine 5'-diphosphatase''', '''nucleoside diphosphate phosphatase''', '''type B nucleoside diphosphatase''', '''GDPase''', '''CDPase''', '''nucleoside 5'-diphosphatase''', '''type L nucleoside diphosphatase''', '''NDPase''', and '''nucleoside diphosphate phosphohydrolase'''. This enzyme participates in [[purine metabolism]] and [[pyrimidine metabolism]].

==Structural studies==

As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2H2N}} and {{PDB link|2H2U}}.

==References==
{{reflist|1}}
* {{cite journal | author = GIBSON DM, AYENGAR P, SANADI DR | date = 1955 | title = A phosphatase specific for nucleoside diphosphates | journal = Biochim. Biophys. Acta. | volume = 16 | pages = 536–8 | pmid = 14389272 | doi = 10.1016/0006-3002(55)90275-4 | issue = 4 }}
* {{cite journal | author = Horecker BL, Hurwitz J and Heppel LA | date = 1957 | title = The synthesis of ribose 5-pyrophosphate and ribose 5-triphosphate | journal = J. Am. Chem. Soc. | volume = 79 | pages = 701–702 | doi = 10.1021/ja01560a054 | issue = 3 }}

{{hydrolase-stub}}

[[Category:EC 3.6.1]]
[[Category:Enzymes of known structure]]

Molybdate-transporting ATPase - Revision history

en>Helpful Pixie Bot: ISBNs (Build KC)