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| {{Infobox enzyme
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| | Name = Hydroxymethylglutaryl-CoA reductase
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| | EC_number = 1.1.1.88
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| | CAS_number = 37250-24-1
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| | IUBMB_EC_number = 1/1/1/88
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| | GO_code =
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| }}
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| In [[enzymology]], a '''Hydroxymethylglutaryl-CoA reductase''' ({{EC number|1.1.1.88}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| : (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup> | |
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are (R)-[[mevalonate]], [[coenzyme A|CoA]], and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[3-hydroxy-3-methylglutaryl-CoA]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)'''.<ref>{{cite journal | title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) |author = Fimognari, G.M. and Rodwell, V.W. |journal = Biochemistry |year = 1965 |volume = 4 |pages = 2086–2090 |pmid = }}</ref> Other names in common use include '''beta-hydroxy-beta-methylglutaryl coenzyme A reductase''', '''beta-hydroxy-beta-methylglutaryl CoA-reductase''', '''3-hydroxy-3-methylglutaryl coenzyme A reductase''', and '''hydroxymethylglutaryl coenzyme A reductase'''.
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| == References ==
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| {{reflist}}
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| == External links ==
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| * {{MeshName|Hydroxymethylglutaryl-CoA+reductase}}
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| [[Category:EC 1.1.1]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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Latest revision as of 22:08, 30 September 2014
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