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| {{enzyme
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| | Name = 27-hydroxycholesterol 7-alpha-monooxygenase
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| | EC_number = 1.14.13.60
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| | CAS_number = 149316-80-3
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| | IUBMB_EC_number = 1/14/13/60
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| | GO_code = 0047092
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| In [[enzymology]], a '''27-hydroxycholesterol 7alpha-monooxygenase''' ({{EC number|1.14.13.60}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :27-hydroxycholesterol + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 7alpha,27-dihydroxycholesterol + NADP<sup>+</sup> + H<sub>2</sub>O
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| The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[27-hydroxycholesterol]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[7alpha,27-dihydroxycholesterol]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor. The systematic name of this enzyme class is '''27-hydroxycholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)'''. This enzyme is also called '''27-hydroxycholesterol 7alpha-hydroxylase'''. It employs one [[cofactor (biochemistry)|cofactor]], [[heme-thiolate(P-450)]].
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| ==References== | |
| {{reflist|1}}
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| * {{cite journal | author = Kumiko OM, Budai K and Javitt NB | date = 1993 | title = Cholesterol and 27-hydroxycholesterol 7alpha-hydroxylation: evidence for two different enzymes | journal = J. Lipid Res. | volume = 34 | pages = 581–588 }}
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| {{1.14.13-enzyme-stub}}
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| [[Category:EC 1.14.13]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:Heme enzymes]]
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| [[Category:Enzymes of unknown structure]]
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Latest revision as of 17:00, 27 August 2014
Hi there. Let me begin by introducing the author, her name is Sophia. What me and my family love is to climb but I'm thinking on starting something new. My working day job is an information officer but I've already applied for another one. I've always loved living in Mississippi.
Look at my web blog :: email psychic readings (dgmensa.org)