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The '''sum activity of peripheral deiodinases''' (GD, also referred to as deiodination capacity, total deiodinase activity or SPINA-GD) is the maximum amount of [[triiodothyronine]] produced per time-unit under conditions of substrate saturation. It is assumed to reflect the activity of [[deiodinase]]s outside the [[central nervous system]].


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GD can be determined experimentally by exposing a cell culture system to saturating concentrations of T4 and measuring the T3 production.
 
''In vivo'', GD may also be estimated from equilibrium levels of T4 and T3. It is obtained with
 
<math>\hat G_D  = {{\beta _{31} (K_{M1}  + [FT_4 ])(1 + K_{30} [TBG])[FT_3 ]} \over {\alpha _{31} [FT_4 ]}}</math>
 
or
 
<math>\hat G_D  = {{\beta _{31} (K_{M1}  + [FT_4 ])[TT_3 ]} \over {\alpha _{31} [FT_4 ]}}</math>
 
<math>\alpha _{31}</math>: [[Dilution]] factor for T3 (reciprocal of apparent volume of distribution, 0.026 l<sup>−1</sup>)<br />
<math>\beta _{31}</math>: [[Clearance (medicine)|Clearance]] exponent for T3 (8e-6 sec<sup>−1</sup>)<br />
''K''<sub>''M''1</sub>: [[Dissociation constant]] of type-1-deiodinase (5e-7&nbsp;mol/l)<br />
''K''<sub>30</sub>: Dissociation constant T3-TBG (2e9 l/mol)<ref name=dietrich2002>{{Cite book
|publisher = Logos-Verlag Berlin
|isbn = 978-3-89722-850-4
|publication-place = Berlin, Germany
|title = Der Hypophysen-Schilddrüsen-Regelkreis
|url = http://openlibrary.org/books/OL24586469M/Der_Hypophysen-Schilddrüsen-Regelkreis
|author = Dietrich, J. W.
|publication-date = 2002
|oclc = 50451543
|id = 3897228505
|postscript = <!-- Bot inserted parameter. Either remove it; or change its value to "." for the cite to end in a ".", as necessary. -->{{inconsistent citations}}
}}</ref>
 
{| class="wikitable"
|'''Lower limit'''||'''Upper limit'''||'''Unit'''
|-
| 20<ref name=dietrich2002/> || 40<ref name=dietrich2002/> ||  nmol/s
|-
|}
 
== Clinical significance ==
GD correlates with [[body mass index]]<ref name=dietrich2002/><ref name="Liu2012">{{cite journal | pmid = 22874844 | title=Nonthyroidal Illness Syndrome: ist it Far Away From Crohn's Disease? | year=2013 | author=Liu S, Ren J, Zhao Y, Han G, Hong Z, Yan D, Chen J, Gu G, Wang G, Wang X, Fan C, Li J | journal=J Clin Gastroenterol. | volume = 47 | issue = 2 | pages = 153–9 | doi = 10.1097/MCG.0b013e318254ea8a}}</ref><ref>Dietrich JW, Landgrafe, G, Fotiadou, EH. [http://www.hindawi.com/journals/jtr/2012/351864/ TSH and Thyrotropic Agonists: Key Actors in Thyroid Homeostasis] Journal of Thyroid Research, vol. 2012, Article ID 351864, 29 pages, 2012. [[doi:10.1155/2012/351864]]. PMID 23365787.</ref> and thyrotropin levels,<ref>Hoermann R, Midgley JE, Larisch R, Dietrich JW. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur J Endocrinol. 2013;168(2):271-80. [[doi:10.1530/EJE-12-0819]]. PMID 23184912.</ref> and it is reduced in [[Euthyroid sick syndrome|nonthyroidal illness]] with hypodeiodination.<ref name=Rosolowska-Huszcz2005>{{cite journal | pmid = 16230785 | volume=27 | issue=3 | title=Influence of low protein diet on nonthyroidal illness syndrome in chronic renal failure | year=2005 | month=August | author=Rosolowska-Huszcz D, Kozlowska L, Rydzewski A | journal=Endocrine | pages=283–8 | doi=10.1385/ENDO:27:3:283}}</ref><ref name=Liu2012 /><ref>Han G, Ren J, Liu S, Gu G, Ren H, Yan D, Chen J, Wang G, Zhou B, Wu X, Yuan Y, Li J. Nonthyroidal illness syndrome in enterocutaneous fistulas. Am J Surg. 2013 Sep;206(3):386-92 [[doi:10.1016/j.amjsurg.2012.12.011]]. PMID 23809674.</ref>
 
==See also==
* [[Thyroid function tests]]
* [[Thyroid's secretory capacity]]
 
== External links ==
* [http://spina.sf.net SPINA Thyr: Open source software for calculating GT and GD]
 
==References==
{{reflist}}
 
[[Category:Chemical pathology]]
[[Category:Blood tests]]
[[Category:Endocrine procedures]]
[[Category:Thyroidological methods]]

Latest revision as of 22:11, 26 June 2013

The sum activity of peripheral deiodinases (GD, also referred to as deiodination capacity, total deiodinase activity or SPINA-GD) is the maximum amount of triiodothyronine produced per time-unit under conditions of substrate saturation. It is assumed to reflect the activity of deiodinases outside the central nervous system.

GD can be determined experimentally by exposing a cell culture system to saturating concentrations of T4 and measuring the T3 production.

In vivo, GD may also be estimated from equilibrium levels of T4 and T3. It is obtained with

G^D=β31(KM1+[FT4])(1+K30[TBG])[FT3]α31[FT4]

or

G^D=β31(KM1+[FT4])[TT3]α31[FT4]

α31: Dilution factor for T3 (reciprocal of apparent volume of distribution, 0.026 l−1)
β31: Clearance exponent for T3 (8e-6 sec−1)
KM1: Dissociation constant of type-1-deiodinase (5e-7 mol/l)
K30: Dissociation constant T3-TBG (2e9 l/mol)[1]

Lower limit Upper limit Unit
20[1] 40[1] nmol/s

Clinical significance

GD correlates with body mass index[1][2][3] and thyrotropin levels,[4] and it is reduced in nonthyroidal illness with hypodeiodination.[5][2][6]

See also

External links

References

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  4. Hoermann R, Midgley JE, Larisch R, Dietrich JW. Is pituitary TSH an adequate measure of thyroid hormone-controlled homoeostasis during thyroxine treatment? Eur J Endocrinol. 2013;168(2):271-80. doi:10.1530/EJE-12-0819. PMID 23184912.
  5. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

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  6. Han G, Ren J, Liu S, Gu G, Ren H, Yan D, Chen J, Wang G, Zhou B, Wu X, Yuan Y, Li J. Nonthyroidal illness syndrome in enterocutaneous fistulas. Am J Surg. 2013 Sep;206(3):386-92 doi:10.1016/j.amjsurg.2012.12.011. PMID 23809674.