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| {{enzyme
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| | Name = 3-Hydroxybutyrate dehydrogenase
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| | EC_number = 1.1.1.30
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| | CAS_number = 9028-38-0
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| | IUBMB_EC_number = 1/1/1/30
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| | GO_code = 0003858
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| In [[enzyme|enzymology]], a '''3-hydroxybutyrate dehydrogenase''' ({{EC number|1.1.1.30}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(R)-3-hydroxybutanoate + NAD<sup>+</sup> <math>\rightleftharpoons</math> acetoacetate + NADH + H<sup>+</sup>
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| Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[beta-Hydroxybutyric acid|(R)-3-hydroxybutanoate]] and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[acetoacetic acid|acetoacetate]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, to be specific, those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(R)-3-hydroxybutanoate:NAD<sup>+</sup> oxidoreductase'''. Other names in common use include '''NAD<sup>+</sup>-beta-hydroxybutyrate dehydrogenase''', '''hydroxybutyrate oxidoreductase''', '''beta-hydroxybutyrate dehydrogenase''', '''D-beta-hydroxybutyrate dehydrogenase''', '''D-3-hydroxybutyrate dehydrogenase''', '''D-(-)-3-hydroxybutyrate dehydrogenase''', '''beta-hydroxybutyric acid dehydrogenase''', '''3-D-hydroxybutyrate dehydrogenase''', and '''beta-hydroxybutyric dehydrogenase'''. This enzyme participates in [[ketone#Biochemistry|synthesis and degradation of ketone bodies]] and [[Butanoate#Butanoate fermentation|butanoate metabolism]].
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| == Structural studies == | |
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| As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1WMB}} and {{PDB link|1X1T}}.
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| == See also ==
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| * [[BDH1]]
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| == References ==
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| {{reflist|1}}
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| * {{cite journal | author = Bergmeyer HU, Gawehn K, Klotzsch H, Krebs HA, Williamson DH | date = 1967 | title = Purification and properties of crystalline 3-hydroxybutyrate dehydrogenase from ''Rhodopseudomonas spheroides'' | journal = Biochem. J. | volume = 102 | pages = 423–31 | pmid = 4291491 | issue = 2 | pmc = 1270263 }}
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| * {{cite journal | author = Delafield FP, Cooksey KE, Doudoroff M | date = 1965 | title = beta-Hydroxybutyric dehydrogenase and dimer hydrolase of ''Pseudomonas lemoignei'' | journal = J. Biol. Chem. | volume = 240 | pages = 4023–8 | pmid = 4954074 | issue = 10 }}
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| * {{cite journal | author = Lehninger AL, Sudduth HC and Wise JB | date = 1960 | title = D-beta-Hydroxybutyric dehydrogenase of mitochondria | journal = J. Biol. Chem. | volume = 235 | pages = 2450–2455 | pmid = 14415394 }}
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| [[Category:EC 1.1.1]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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