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| {{enzyme
| | Hello from Germany. I'm glad to be here. My first name is Samual. <br>I live in a small town called Wuppertal Elberfeld in nothern Germany.<br>I was also born in Wuppertal Elberfeld 38 years ago. Married in February year 2003. I'm working at the university.<br><br>My web page; [https://www.youtube.com/watch?v=ZAPaq8K3NUg Friv Juegos] |
| | Name = methenyltetrahydrofolate cyclohydrolase
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| | EC_number = 3.5.4.9
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| | CAS_number = 9027-97-8
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| | IUBMB_EC_number = 3/5/4/9
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| | GO_code = 0004477
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| In [[enzymology]], a '''methenyltetrahydrofolate cyclohydrolase''' ({{EC number|3.5.4.9}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :5,10-methenyltetrahydrofolate + H<sub>2</sub>O <math>\rightleftharpoons</math> 10-formyltetrahydrofolate
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| Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[5,10-methenyltetrahydrofolate]] and [[water|H<sub>2</sub>O]], whereas its [[product (chemistry)|product]] is [[10-formyltetrahydrofolate]].
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| This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is '''5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)'''. Other names in common use include '''Citrovorum factor cyclodehydrase''', '''cyclohydrolase''', and '''formyl-methenyl-methylenetetrahydrofolate synthetase (combined)'''. This enzyme participates in [[glyoxylate and dicarboxylate metabolism]] and [[one carbon pool by folate]].
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| ==Structural studies==
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| As of late 2007, 6 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1A4I}}, {{PDB link|1DIA}}, {{PDB link|1DIB}}, {{PDB link|1DIG}}, {{PDB link|2C2X}}, and {{PDB link|2C2Y}}.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Rabinowitz JC and Pricer WE | date = 1956 | title = The enzymatic synthesis of N10-formyltetrahydrofolic acid and its role in ATP formation during formiminoglycine degradation | journal = J. Am. Chem. Soc. | volume = 78 | pages = 4176–4178 | doi = 10.1021/ja01597a094 | issue = 16 }}
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| * {{cite journal | author = Tabor H and Wyngarden L | date = 1959 | title = The enzymatic formation of formiminotetrahydrofolic acid, 5,10-methenyltetrahydrofolic acid, and 10-formyltetrahydrofolic acid in the metabolism of formiminoglutamic acid | journal = J. Biol. Chem. | volume = 234 | pages = 1830–1849 | pmid=13672973 | issue = 7}}
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| {{hydrolase-stub}}
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| [[Category:EC 3.5.4]] | |
| [[Category:Enzymes of known structure]]
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Hello from Germany. I'm glad to be here. My first name is Samual.
I live in a small town called Wuppertal Elberfeld in nothern Germany.
I was also born in Wuppertal Elberfeld 38 years ago. Married in February year 2003. I'm working at the university.
My web page; Friv Juegos