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{{about|the biological application of the Nernst equation|the general equation|Nernst equation}}
In [[mathematics]], an '''addition chain''' for computing a positive integer ''n'' can be given by a [[sequence]] of [[natural number]]s ''v'' and a sequence of index pairs ''w'' such that each term in ''v'' is the sum of two previous terms, the indices of those terms being specified by ''w'':


In a [[biological membrane]], the '''reversal potential''' (also known as the '''Nernst potential''') of an [[ion]] is the [[membrane potential]] at which there is no net (overall) flow of that particular ion from one side of the membrane to the other. In the case of [[post-synaptic]] [[neuron]]s, the reversal potential is the membrane potential at which a given [[neurotransmitter]] causes no net current flow of ions through that neurotransmitter [[Receptor (biochemistry)|receptor's]] [[ion channel]].<ref name="Purves" >{{cite book | author = Dale Purves, et al. | title = Neuroscience, 4th Edition | publisher = Sinauer Associates | pages = 109–11 | year = 2008 | isbn = 978-0-87893-697-7}}</ref>
: ''v'' =(''v''<sub>0</sub>,...,''v''<sub>''s''</sub>), with ''v''<sub>0</sub> = 1  and ''v''<sub>''s''</sub> = ''n''
:for each 0< ''i'' ≤ ''s'' holds: ''v''<sub>''i''</sub> = ''v''<sub>''j''</sub> + ''v''<sub>''k''</sub>, with ''w''<sub>''i''</sub>=(''j,k'') and 0 ≤ ''j,k'' ≤  ''i''&nbsp;−&nbsp;1


In a single-ion system, ''reversal potential'' is synonymous with '''equilibrium potential'''; their numerical values are identical. The two terms refer to different aspects of the difference in membrane potential. ''Equilibrium'' refers to the fact that the net ion flux at a particular voltage is zero. That is, the outward and inward rates of ion movement are the same; the ion flux is in equilibrium. ''Reversal'' refers to the fact that a change of membrane potential on either side of the equilibrium potential reverses the overall direction of ion flux.<ref name="Purves" />
Often only ''v'' is given since it is easy to extract ''w'' from ''v'', but sometimes ''w'' is not uniquely reconstructible. An introduction is given in.<ref>D. E. Knuth, ''The Art of Computer Programming'', Vol 2, "Seminumerical Algorithms", Section 4.6.3, 3rd edition, 1997</ref>


The reversal potential is often called the "Nernst potential", as it can be calculated from the [[Nernst equation]]. Ion channels conduct most of the flow of simple ions in and out of [[cell (biology)|cells]]. When a channel type that is selective to one species of ion dominates within the membrane of a cell (because other ion channels are closed, for example) then the voltage inside the cell will equilibrate (i.e. become equal) to the reversal potential for that ion (assuming the outside of the cell is at 0 volts). For example, the [[resting potential]] of most cells is close to the [[potassium|K]]<sup>+</sup> (potassium ion) reversal potential. This is because at resting potential, potassium conductance dominates. During a typical [[action potential]], the small resting ion conductance mediated by potassium channels is overwhelmed by the opening of a large number of [[sodium|Na]]<sup>+</sup> (sodium ion) channels, which brings the membrane potential close to the reversal potential of sodium.
==Examples==
As an example: ''v'' = (1,2,3,6,12,24,30,31) is an addition chain for 31 of length 7, since
:2 = 1 + 1
:3 = 2 + 1
:6 = 3 + 3
:12 = 6 + 6
:24 = 12 + 12
:30 = 24 + 6
:31 = 30 + 1


The relationship between the terms "reversal potential" and "equilibrium potential" only holds true for single-ion systems. In multi-ion systems, there are areas of the cell membrane where the summed currents of the multiple ions will equal zero. While this is a reversal potential in the sense that membrane potential reverses direction, it is not an equilibrium potential because not all (and in some cases, none) of the ions are in equilibrium and thus have net fluxes across the membrane. When a cell has significant permeabilities to more than one ion, the cell potential can be calculated from the [[Goldman-Hodgkin-Katz equation]] rather than the Nernst equation.
Addition chains can be used for [[addition-chain exponentiation]]: so for example we only need 7 [[multiplication]]s to calculate 5<sup>31</sup>:
:5<sup>2</sup> = 5<sup>1</sup> × 5<sup>1</sup>
:5<sup>3</sup> = 5<sup>2</sup> × 5<sup>1</sup>
:5<sup>6</sup> = 5<sup>3</sup> × 5<sup>3</sup>
:5<sup>12</sup> = 5<sup>6</sup> × 5<sup>6</sup>
:5<sup>24</sup> = 5<sup>12</sup> × 5<sup>12</sup>
:5<sup>30</sup> = 5<sup>24</sup> × 5<sup>6</sup>
:5<sup>31</sup> = 5<sup>30</sup> × 5<sup>1</sup>


==Mathematical models==
==Methods for computing addition chains==
The term ''driving force'' is related to equilibrium potential, and is likewise useful in understanding the current in biological membranes. Driving force refers to the difference between the actual membrane potential and an ion's equilibrium potential. It is defined by the following equation:
Calculating an addition chain of minimal length is not easy; a generalized version of the problem, in which one must find a chain that simultaneously forms each of a sequence of values, is NP-complete.<ref>{{Cite journal|first1=Peter|last1=Downey|first2=Benton|last2=Leong|first3=Ravi|last3=Sethi|title=Computing sequences with addition chains|journal=SIAM Journal on Computing|volume=10|issue=3|year=1981|pages=638–646|doi=10.1137/0210047}}. A number of other papers state that finding a single addition chain is NP-complete, citing this paper, but it does not claim or prove such a result.</ref> There is no known algorithm which can calculate a minimal addition chain for a given number with any guarantees of reasonable timing or small memory usage. However, several techniques to calculate relatively short chains exist.
One very well known technique to calculate relatively short addition chains is the ''binary method'', similar to [[exponentiation by squaring]]. Other well-known methods are the ''factor method'' and ''window method''.{{Citation needed|date=December 2009}}


:<math>{I_{ion}} = {g_{ion}} ({V_m}-{E_{ion}})\,</math> where <math>{V_m}-{E_{ion}}</math> is the Driving Force.
==Chain length==
Let <math>l(n)</math> denote the smallest ''s'' so that there exists an addition chain
of length ''s'' which computes ''n''.
It is known that <ref>A. Schonhage A lower bound on the length of addition chains, Theoret. Comput. Sci. 1 (1975), 1–12.</ref>
:<math>\log(n)+ \log(\nu(n))-2.13\leq l(n) \leq \log(n) + \log(n)(1+o(1))/\log(\log(n))</math>,
where <math>\nu(n)</math> is [[Hamming weight]] of binary expansion of ''n''.


In words, this equation says that: the ionic current (I<sub>ion</sub>) is equal to that ion's conductance (g<sub>ion</sub>) multiplied by the driving force, which is represented by the difference between the membrane potential and the ion's equilibrium potential (i.e. V<sub>m</sub>-E<sub>ion</sub>). Note that the ionic current will be zero if the membrane is impermeable (g<sub>ion</sub> = 0) to the ion in question, regardless of the size of the driving force.
It is clear that ''l''(2''n'') ≤ ''l''(''n'')+1. Strict inequality is possible, as ''l''(382) = ''l''(191) = 11, observed by Knuth.<ref name=G169/>


A related equation (which is derived from the more general equation above) determines the magnitude of an [[end plate current]] (EPC), at a given membrane potential, in the [[neuromuscular junction]]:
==Brauer chain==
A '''Brauer chain''' or '''star addition chain''' is an addition chain in which one of the summands is always the previous chain: that is,


:<math>EPC = {g_{ACh}} ({V_m}-{E_{rev}})\,</math>
:for each ''k''>0: ''a''<sub>''k''</sub> = ''a''<sub>''k-1''</sub> + ''a''<sub>''j''</sub> for some ''j'' < ''k''.


where EPC is the end plate current, g<sub>ACh</sub> is the ionic conductance activated by [[acetylcholine]], V<sub>m</sub> is the membrane potential, and E<sub>rev</sub> is the reversal potential. When the membrane potential is equal to the reversal potential, V<sub>m</sub>-E<sub>rev</sub> is equal to 0 and there is no driving force on the ions involved.<ref name="Purves" />
A '''Brauer number''' is one for which the Brauer chain is minimal.<ref name=G169/>


==Use in research==
Brauer proved that
When V<sub>m</sub> is at the reversal potential (V<sub>m</sub>-E<sub>rev</sub> is equal to 0), the identity of the ions that flow during an EPC can be deduced by comparing the reversal potential of the EPC to the equilibrium potential for various ions. For instance several excitatory [[ionotropic]] ligand-gated [[neurotransmitter]] [[Receptor (biochemistry)|receptors]] including [[glutamate receptor]]s ([[AMPA]], [[NMDA]], and [[kainate]]), [[nicotinic]] [[acetylcholine]] (nACh), and [[serotonin]] (5-HT<sub>3</sub>) receptors are nonselective cation channels that pass Na<sup>+</sup> and K<sup>+</sup> in nearly equal proportions, giving an equilibrium potential close to 0 mV. The inhibitory ionotropic ligand-gated neurotransmitter receptors that carry Cl<sup></sup>, such as [[GABA]]<sub>A</sub> and [[glycine]] receptors, have equilibrium potentials close to the resting potential (approximately –70 mV) in neurons.<ref name="Purves" />
:''l''*(2<sup>''n''</sup>&minus;1) &le; ''n'' &minus; 1 + ''l''*(''n'')
where ''l''* is the length of the shortest star chain.  For many values of ''n'',and in particular for ''n''&nbsp;≤&nbsp;2500, they are equal: ''l''(''n'')&nbsp;=&nbsp;''l''*(''n''). But Hansen showed that there are some values of ''n'' for which ''l''(''n'')&nbsp;≠&nbsp;''l''*(''n''), such as ''n''&nbsp;=&nbsp;2<sup>6106</sup>&nbsp;+&nbsp;2<sup>3048</sup>&nbsp;+&nbsp;2<sup>2032</sup>&nbsp;+&nbsp;2<sup>2016</sup>&nbsp;+&nbsp;1 which has ''l''*(''n'')&nbsp;=&nbsp;6110, ''l''(''n'')&nbsp;≤&nbsp;6109.


This line of reasoning led to the development of experiments (by Akira Takeuchi and Noriko Takeuchi in 1960) that proved that acetylcholine-activated ion channels are approximately equally permeable to Na<sup>+</sup> and K<sup>+</sup> ions. The experiment was performed by lowering the external Na<sup>+</sup> concentration, which lowers (more negative) the Na<sup>+</sup> equilibrium potential and produces a negative shift in reversal potential. Conversely, increasing the external K<sup>+</sup> concentration raises (more positive) the K<sup>+</sup> equilibrium potential and produces a positive shift in reversal potential.<ref name="Purves" />
==Scholz conjecture==
{{main|Scholz conjecture}}
The [[Scholz conjecture]] (sometimes called the ''Scholz–Brauer'' or ''Brauer–Scholz conjecture''), named after [[A. Scholz]] and Alfred T. Brauer), is a [[conjecture]] from 1937 stating that
:''l''(2<sup>''n''</sup>&nbsp;&minus;&nbsp;1)&nbsp;&le;&nbsp;''n''&nbsp;&minus;&nbsp;1&nbsp;+&nbsp;''l''(''n'') .
 
N. Clift checked this by computer for&nbsp;''n''&nbsp;≤&nbsp;46.  It is known to be true for Brauer numbers.<ref name=G169>Guy (2004) p.169</ref>


==See also==
==See also==
*[[Electrochemical potential]]
* [[Addition chain exponentiation]]
*[[Cell potential]]
* [[Addition-subtraction chain]]
*[[Goldman equation]]
* [[Vectorial addition chain]]
* [[Lucas chain]]


==References==
==References==
{{reflist}}
{{reflist}}
*{{cite journal | last1=Brauer | first1=Alfred | title=On addition chains | doi=10.1090/S0002-9904-1939-07068-7  | mr=0000245  | year=1939 | journal=[[Bulletin of the American Mathematical Society]] | issn=0002-9904 | volume=45 | issue=10 | pages=736–739}}
* {{cite book|author=Richard K. Guy|authorlink=Richard K. Guy|title=[[Unsolved Problems in Number Theory]]|publisher=[[Springer-Verlag]]|year=2004|isbn=0-387-20860-7|oclc=54611248 | zbl=1058.11001}}  Section C6.
== External links ==
* http://wwwhomes.uni-bielefeld.de/achim/addition_chain.html
* {{SloanesRef |sequencenumber=A003313|name=Length of shortest addition chain for n}}
*[http://www.numdam.org/item?id=JTNB_1994__6_1_21_0 F. Bergeron, J. Berstel. S. Brlek "Efficient computation of addition chains"]


==External links==
{{DEFAULTSORT:Addition Chain}}
* [http://www.nernstgoldman.physiology.arizona.edu/ Nernst/Goldman Equation Simulator]
[[Category:Addition chains|*]]
* [http://www.physiologyweb.com/calculators/nernst_potential_calculator.html Nernst Equation Calculator]
* [http://www.physiologyweb.com/calculators/ghk_equation_calculator.html Goldman-Hodgkin-Katz Equation Calculator]
* [http://www.physiologyweb.com/calculators/electrochemical_driving_force_calculator.html Electrochemical Driving Force Calculator]


[[Category:Membrane biology]]
[[es:Suma encadenada]]

Revision as of 08:55, 12 August 2014

In mathematics, an addition chain for computing a positive integer n can be given by a sequence of natural numbers v and a sequence of index pairs w such that each term in v is the sum of two previous terms, the indices of those terms being specified by w:

v =(v0,...,vs), with v0 = 1 and vs = n
for each 0< is holds: vi = vj + vk, with wi=(j,k) and 0 ≤ j,ki − 1

Often only v is given since it is easy to extract w from v, but sometimes w is not uniquely reconstructible. An introduction is given in.[1]

Examples

As an example: v = (1,2,3,6,12,24,30,31) is an addition chain for 31 of length 7, since

2 = 1 + 1
3 = 2 + 1
6 = 3 + 3
12 = 6 + 6
24 = 12 + 12
30 = 24 + 6
31 = 30 + 1

Addition chains can be used for addition-chain exponentiation: so for example we only need 7 multiplications to calculate 531:

52 = 51 × 51
53 = 52 × 51
56 = 53 × 53
512 = 56 × 56
524 = 512 × 512
530 = 524 × 56
531 = 530 × 51

Methods for computing addition chains

Calculating an addition chain of minimal length is not easy; a generalized version of the problem, in which one must find a chain that simultaneously forms each of a sequence of values, is NP-complete.[2] There is no known algorithm which can calculate a minimal addition chain for a given number with any guarantees of reasonable timing or small memory usage. However, several techniques to calculate relatively short chains exist. One very well known technique to calculate relatively short addition chains is the binary method, similar to exponentiation by squaring. Other well-known methods are the factor method and window method.Potter or Ceramic Artist Truman Bedell from Rexton, has interests which include ceramics, best property developers in singapore developers in singapore and scrabble. Was especially enthused after visiting Alejandro de Humboldt National Park.

Chain length

Let l(n) denote the smallest s so that there exists an addition chain of length s which computes n. It is known that [3]

log(n)+log(ν(n))2.13l(n)log(n)+log(n)(1+o(1))/log(log(n)),

where ν(n) is Hamming weight of binary expansion of n.

It is clear that l(2n) ≤ l(n)+1. Strict inequality is possible, as l(382) = l(191) = 11, observed by Knuth.[4]

Brauer chain

A Brauer chain or star addition chain is an addition chain in which one of the summands is always the previous chain: that is,

for each k>0: ak = ak-1 + aj for some j < k.

A Brauer number is one for which the Brauer chain is minimal.[4]

Brauer proved that

l*(2n−1) ≤ n − 1 + l*(n)

where l* is the length of the shortest star chain. For many values of n,and in particular for n ≤ 2500, they are equal: l(n) = l*(n). But Hansen showed that there are some values of n for which l(n) ≠ l*(n), such as n = 26106 + 23048 + 22032 + 22016 + 1 which has l*(n) = 6110, l(n) ≤ 6109.

Scholz conjecture

Mining Engineer (Excluding Oil ) Truman from Alma, loves to spend time knotting, largest property developers in singapore developers in singapore and stamp collecting. Recently had a family visit to Urnes Stave Church. The Scholz conjecture (sometimes called the Scholz–Brauer or Brauer–Scholz conjecture), named after A. Scholz and Alfred T. Brauer), is a conjecture from 1937 stating that

l(2n − 1) ≤ n − 1 + l(n) .

N. Clift checked this by computer for n ≤ 46. It is known to be true for Brauer numbers.[4]

See also

References

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External links

es:Suma encadenada

  1. D. E. Knuth, The Art of Computer Programming, Vol 2, "Seminumerical Algorithms", Section 4.6.3, 3rd edition, 1997
  2. One of the biggest reasons investing in a Singapore new launch is an effective things is as a result of it is doable to be lent massive quantities of money at very low interest rates that you should utilize to purchase it. Then, if property values continue to go up, then you'll get a really high return on funding (ROI). Simply make sure you purchase one of the higher properties, reminiscent of the ones at Fernvale the Riverbank or any Singapore landed property Get Earnings by means of Renting

    In its statement, the singapore property listing - website link, government claimed that the majority citizens buying their first residence won't be hurt by the new measures. Some concessions can even be prolonged to chose teams of consumers, similar to married couples with a minimum of one Singaporean partner who are purchasing their second property so long as they intend to promote their first residential property. Lower the LTV limit on housing loans granted by monetary establishments regulated by MAS from 70% to 60% for property purchasers who are individuals with a number of outstanding housing loans on the time of the brand new housing purchase. Singapore Property Measures - 30 August 2010 The most popular seek for the number of bedrooms in Singapore is 4, followed by 2 and three. Lush Acres EC @ Sengkang

    Discover out more about real estate funding in the area, together with info on international funding incentives and property possession. Many Singaporeans have been investing in property across the causeway in recent years, attracted by comparatively low prices. However, those who need to exit their investments quickly are likely to face significant challenges when trying to sell their property – and could finally be stuck with a property they can't sell. Career improvement programmes, in-house valuation, auctions and administrative help, venture advertising and marketing, skilled talks and traisning are continuously planned for the sales associates to help them obtain better outcomes for his or her shoppers while at Knight Frank Singapore. No change Present Rules

    Extending the tax exemption would help. The exemption, which may be as a lot as $2 million per family, covers individuals who negotiate a principal reduction on their existing mortgage, sell their house short (i.e., for lower than the excellent loans), or take part in a foreclosure course of. An extension of theexemption would seem like a common-sense means to assist stabilize the housing market, but the political turmoil around the fiscal-cliff negotiations means widespread sense could not win out. Home Minority Chief Nancy Pelosi (D-Calif.) believes that the mortgage relief provision will be on the table during the grand-cut price talks, in response to communications director Nadeam Elshami. Buying or promoting of blue mild bulbs is unlawful.

    A vendor's stamp duty has been launched on industrial property for the primary time, at rates ranging from 5 per cent to 15 per cent. The Authorities might be trying to reassure the market that they aren't in opposition to foreigners and PRs investing in Singapore's property market. They imposed these measures because of extenuating components available in the market." The sale of new dual-key EC models will even be restricted to multi-generational households only. The models have two separate entrances, permitting grandparents, for example, to dwell separately. The vendor's stamp obligation takes effect right this moment and applies to industrial property and plots which might be offered inside three years of the date of buy. JLL named Best Performing Property Brand for second year running

    The data offered is for normal info purposes only and isn't supposed to be personalised investment or monetary advice. Motley Fool Singapore contributor Stanley Lim would not personal shares in any corporations talked about. Singapore private home costs increased by 1.eight% within the fourth quarter of 2012, up from 0.6% within the earlier quarter. Resale prices of government-built HDB residences which are usually bought by Singaporeans, elevated by 2.5%, quarter on quarter, the quickest acquire in five quarters. And industrial property, prices are actually double the levels of three years ago. No withholding tax in the event you sell your property. All your local information regarding vital HDB policies, condominium launches, land growth, commercial property and more

    There are various methods to go about discovering the precise property. Some local newspapers (together with the Straits Instances ) have categorised property sections and many local property brokers have websites. Now there are some specifics to consider when buying a 'new launch' rental. Intended use of the unit Every sale begins with 10 p.c low cost for finish of season sale; changes to 20 % discount storewide; follows by additional reduction of fiftyand ends with last discount of 70 % or extra. Typically there is even a warehouse sale or transferring out sale with huge mark-down of costs for stock clearance. Deborah Regulation from Expat Realtor shares her property market update, plus prime rental residences and houses at the moment available to lease Esparina EC @ Sengkang. A number of other papers state that finding a single addition chain is NP-complete, citing this paper, but it does not claim or prove such a result.
  3. A. Schonhage A lower bound on the length of addition chains, Theoret. Comput. Sci. 1 (1975), 1–12.
  4. 4.0 4.1 4.2 Guy (2004) p.169