Formamidase: Difference between revisions

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{{enzyme
| Name = glutamin-(asparagin-)ase
| EC_number = 3.5.1.38
| CAS_number = 39335-03-0
| IUBMB_EC_number = 3/5/1/38
| GO_code = 0050417
| image =
| width =
| caption =
}}
In [[enzymology]], a '''glutamin-(asparagin-)ase''' ({{EC number|3.5.1.38}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:L-glutamine + H<sub>2</sub>O <math>\rightleftharpoons</math> L-glutamate + NH<sub>3</sub>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[L-glutamine]] and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[L-glutamate]] and [[ammonia|NH<sub>3</sub>]].
 
This enzyme belongs to the family of [[hydrolase]]s, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is '''L-glutamine(L-asparagine) amidohydrolase'''. This enzyme participates in 4 [[metabolism|metabolic pathways]]: [[glutamate metabolism]], [[alanine and aspartate metabolism]], [[d-glutamine and d-glutamate metabolism]], and [[nitrogen metabolism]].
 
==Structural studies==
 
As of late 2007, 3 [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|1DJO}}, {{PDB link|1DJP}}, and {{PDB link|4PGA}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Roberts J, Holcenberg JS, Dolowy WC | date = 1972 | title = Isolation, crystallization, and properties of Achromobacteraceae glutaminase-asparaginase with antitumor activity | journal = J. Biol. Chem. | volume = 247 | pages = 84&ndash;90  | pmid = 5017769 | issue = 1 }}
 
{{hydrolase-stub}}
 
[[Category:Hydrolases acting on nonpeptide C-N bonds]]
[[Category:Enzymes of known structure]]

Revision as of 16:44, 13 May 2013

Template:Enzyme In enzymology, a glutamin-(asparagin-)ase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

L-glutamine + H2O L-glutamate + NH3

Thus, the two substrates of this enzyme are L-glutamine and H2O, whereas its two products are L-glutamate and NH3.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-glutamine(L-asparagine) amidohydrolase. This enzyme participates in 4 metabolic pathways: glutamate metabolism, alanine and aspartate metabolism, d-glutamine and d-glutamate metabolism, and nitrogen metabolism.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link, Template:PDB link, and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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