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{{enzyme
| Name = acridone synthase
| EC_number = 2.3.1.159
| CAS_number = 99085-53-7
| IUBMB_EC_number = 2/3/1/159
| GO_code = 0050635
| image =
| width =
| caption =
}}
In [[enzymology]], an '''acridone synthase''' ({{EC number|2.3.1.159}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


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:3 malonyl-CoA + N-methylanthraniloyl-CoA <math>\rightleftharpoons</math> 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO<sub>2</sub>
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[malonyl-CoA]] and [[N-methylanthraniloyl-CoA]], whereas its 3 [[product (chemistry)|products]] are [[coenzyme A|CoA]], [[1,3-dihydroxy-N-methylacridone]], and [[carbon dioxide|CO<sub>2</sub>]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those [[acyltransferase]]s transferring groups other than aminoacyl groups. The systematic name of this enzyme class is '''malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing)'''. This enzyme participates in [[acridone alkaloid biosynthesis]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Baumert A, Maier W, Groger D, Deutzmann R | date = 1994 | title = Purification and properties of acridone synthase from cell suspension cultures of Ruta graveolens L | journal = Z. Naturforsch. [C]. | volume = 49 | pages = 26&ndash;32  | pmid = 8148006 | issue = 1-2 }}
* {{cite journal | author = Maier W, Baumert A, Schumann B, Furukawa H and Groger D | date = 1993 | title = Synthesis of 1,3-dihydroxy-N-methylacridone and its conversion to rutacridone by cell-free extracts of Ruta-graveolens cell cultures | journal = [[Phytochemistry (journal)|Phytochemistry]]  | volume = 32 | issue = 3 | pages = 691&ndash;698 | doi = 10.1016/S0031-9422(00)95155-0 }}
* {{cite journal | author = Matern U | date = 1999 | title = Native acridone synthases I and II from Ruta graveolens L. form homodimers | journal = FEBS. Lett. | volume = 448 | pages = 135&ndash;40  | pmid = 10217426 | doi = 10.1016/S0014-5793(99)00355-5 | last2 = Springob | first2 = K | last3 = Urbanke | first3 = C | last4 = Ernwein | first4 = C | last5 = Schröder | first5 = G | last6 = Schröder | first6 = J | last7 = Matern | first7 = U | issue = 1 }}
* {{cite journal | author = Junghanns KT, Kneusel RE, Groger D, Matern U | date = 1998 | title = Differential regulation and distribution of acridone synthase in Ruta graveolens | journal = [[Phytochemistry (journal)|Phytochemistry]].  | volume = 49 | pages = 403&ndash;11  | pmid = 9747538 | doi = 10.1016/S0031-9422(98)00104-6 | issue = 2 }}
 
[[Category:EC 2.3.1]]
[[Category:Enzymes of unknown structure]]
 
{{transferase-stub}}

Latest revision as of 21:42, 17 March 2013

Template:Enzyme In enzymology, an acridone synthase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

3 malonyl-CoA + N-methylanthraniloyl-CoA 4 CoA + 1,3-dihydroxy-N-methylacridone + 3 CO2

Thus, the two substrates of this enzyme are malonyl-CoA and N-methylanthraniloyl-CoA, whereas its 3 products are CoA, 1,3-dihydroxy-N-methylacridone, and CO2.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is malonyl-CoA:N-methylanthraniloyl-CoA malonyltransferase (cyclizing). This enzyme participates in acridone alkaloid biosynthesis.

References

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Template:Transferase-stub