Fatty-acid synthase: Difference between revisions

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{{enzyme
| Name = gamma-glutamylcyclotransferase
| EC_number = 2.3.2.4
| CAS_number = 9045-44-7
| IUBMB_EC_number = 2/3/2/4
| GO_code = 0003839
| image =  
| width =  
| caption =  
}}
In [[enzymology]], a '''gamma-glutamylcyclotransferase''' ({{EC number|2.3.2.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:(5-L-glutamyl)-L-amino acid <math>\rightleftharpoons</math> 5-oxoproline + L-amino acid
 
Hence, this enzyme has one [[substrate (biochemistry)|substrate]], [[(5-L-glutamyl)-L-amino acid]], and two [[product (chemistry)|products]], [[5-oxoproline]] and [[L-amino acid]].
 
This enzyme belongs to the family of [[transferase]]s, specifically the [[aminoacyltransferase]]s. The systematic name of this enzyme class is '''(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)'''. Other names in common use include '''gamma-glutamyl-amino acid cyclotransferase''', '''gamma-L-glutamylcyclotransferase''', and '''L-glutamic cyclase'''. This enzyme participates in [[glutathione metabolism]].
 
==Structural studies==
 
As of late 2007, two [[tertiary structure|structures]] have been solved for this class of enzymes, with [[Protein Data Bank|PDB]] accession codes {{PDB link|2PN7}} and {{PDB link|2RBH}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Bodnaryk RP and McGirr L | year = 1973 | title = Purification, properties and function of a unique gamma-glutamyl cyclotransferase from the housefly, Musca domestica L | journal = Biochim. Biophys. Acta  | volume = 315 | pages = 352&ndash;362 }}
* {{cite journal | author = Orlowski M, Richman PG and Meister A | year = 1969 | title = Isolation and properties of gamma-L-glutamylcyclotransferase from human brain | journal = Biochemistry  | volume = 8 | pages = 1048&ndash;1055 | doi = 10.1021/bi00831a036 | pmid=5781001 | issue = 3}}
 
[[Category:EC 2.3.2]]
[[Category:Enzymes of known structure]]
 
 
{{transferase-stub}}

Latest revision as of 22:39, 17 March 2013

Template:Enzyme In enzymology, a gamma-glutamylcyclotransferase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

(5-L-glutamyl)-L-amino acid 5-oxoproline + L-amino acid

Hence, this enzyme has one substrate, (5-L-glutamyl)-L-amino acid, and two products, 5-oxoproline and L-amino acid.

This enzyme belongs to the family of transferases, specifically the aminoacyltransferases. The systematic name of this enzyme class is (5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing). Other names in common use include gamma-glutamyl-amino acid cyclotransferase, gamma-L-glutamylcyclotransferase, and L-glutamic cyclase. This enzyme participates in glutathione metabolism.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes Template:PDB link and Template:PDB link.

References

43 year old Petroleum Engineer Harry from Deep River, usually spends time with hobbies and interests like renting movies, property developers in singapore new condominium and vehicle racing. Constantly enjoys going to destinations like Camino Real de Tierra Adentro.

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Template:Transferase-stub