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{{enzyme
| Name = N-acylneuraminate-9-phosphate synthase
| EC_number = 2.5.1.57
| CAS_number = 9031-58-7
| IUBMB_EC_number = 2/5/1/57
| GO_code = 0047444
| image =
| width =
| caption =
}}
In [[enzymology]], a '''N-acylneuraminate-9-phosphate synthase''' ({{EC number|2.5.1.57}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H<sub>2</sub>O <math>\rightleftharpoons</math> N-acylneuraminate 9-phosphate + phosphate
 
The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[phosphoenolpyruvate]], [[N-acyl-D-mannosamine 6-phosphate]], and [[water|H<sub>2</sub>O]], whereas its two [[product (chemistry)|products]] are [[N-acylneuraminate 9-phosphate]] and [[phosphate]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is '''phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase'''. Other names in common use include '''N-acetylneuraminate 9-phosphate lyase''', '''N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase''', '''N-acetylneuraminate 9-phosphate synthetase''', '''N-acylneuraminate-9-phosphate pyruvate-lyase''', '''(pyruvate-phosphorylating)''', and '''sialic acid 9-phosphate synthetase'''. This enzyme participates in [[aminosugars metabolism]].
 
==Structural studies==
 
As of late 2007, only one [[tertiary structure|structure]] has been solved for this class of enzymes, with the [[Protein Data Bank|PDB]] accession code {{PDB link|1WVO}}.
 
==References==
{{reflist|1}}
* {{cite journal | author = Roseman S, Jourdian GW, Watson D and Rood R | date = 1961 | title = Enzymatic synthesis of sialic acid 9-phosphates | journal = Proc. Natl. Acad. Sci. USA  | volume = 47 | issue = 7 | pages = 958&ndash;961 | doi = 10.1073/pnas.47.7.958 }}
* {{cite journal | author = Watson DR, Jourdian GW, Roseman S | date = 1966 | title = The sialic acids. 8. Sialic acid 9-phosphate synthetase | journal = J. Biol. Chem. | volume = 241 | pages = 5627&ndash;36  | pmid = 5928202 | issue = 23 }}
* {{cite journal | author = Nakata D, Close BE, Colley KJ, Matsuda T, Kitajima K | date = 2000 | title = Molecular cloning and expression of the mouse N-acetylneuraminic acid 9-phosphate synthase which does not have deaminoneuraminic acid (KDN) 9-phosphate synthase activity | journal = Biochem. Biophys. Res. Commun| volume = 273 | pages = 642&ndash;8  | pmid = 10873658 | doi = 10.1006/bbrc.2000.2983 | issue = 2 }}
 
{{transferase-stub}}
 
[[Category:EC 2.5.1]]
[[Category:Enzymes of known structure]]

Latest revision as of 21:49, 19 November 2012

Template:Enzyme In enzymology, a N-acylneuraminate-9-phosphate synthase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

phosphoenolpyruvate + N-acyl-D-mannosamine 6-phosphate + H2O N-acylneuraminate 9-phosphate + phosphate

The 3 substrates of this enzyme are phosphoenolpyruvate, N-acyl-D-mannosamine 6-phosphate, and H2O, whereas its two products are N-acylneuraminate 9-phosphate and phosphate.

This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:N-acyl-D-mannosamine-6-phosphate 1-(2-carboxy-2-oxoethyl)transferase. Other names in common use include N-acetylneuraminate 9-phosphate lyase, N-acetylneuraminate 9-phosphate sialic acid 9-phosphate synthase, N-acetylneuraminate 9-phosphate synthetase, N-acylneuraminate-9-phosphate pyruvate-lyase, (pyruvate-phosphorylating), and sialic acid 9-phosphate synthetase. This enzyme participates in aminosugars metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code Template:PDB link.

References

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Template:Transferase-stub