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| {{Infobox enzyme
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| | Name = Hydroxymethylglutaryl-CoA reductase
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| | EC_number = 1.1.1.88
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| | CAS_number = 37250-24-1
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| | IUBMB_EC_number = 1/1/1/88
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| | GO_code =
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| | image =
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| In [[enzymology]], a '''Hydroxymethylglutaryl-CoA reductase''' ({{EC number|1.1.1.88}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| : (R)-mevalonate + CoA + 2 NAD<sup>+</sup> <math>\rightleftharpoons</math> 3-hydroxy-3-methylglutaryl-CoA + 2 NADH + 2 H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are (R)-[[mevalonate]], [[coenzyme A|CoA]], and [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], whereas its 3 [[product (chemistry)|products]] are [[3-hydroxy-3-methylglutaryl-CoA]], [[nicotinamide adenine dinucleotide|NADH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(R)-mevalonate:NAD<sup>+</sup> oxidoreductase (CoA-acylating)'''.<ref>{{cite journal | title = Substrate-competitive inhibition of bacterial mevalonate:nicotinamide-adenine dinucleotide oxidoreductase (acylating CoA) |author = Fimognari, G.M. and Rodwell, V.W. |journal = Biochemistry |year = 1965 |volume = 4 |pages = 2086–2090 |pmid = }}</ref> Other names in common use include '''beta-hydroxy-beta-methylglutaryl coenzyme A reductase''', '''beta-hydroxy-beta-methylglutaryl CoA-reductase''', '''3-hydroxy-3-methylglutaryl coenzyme A reductase''', and '''hydroxymethylglutaryl coenzyme A reductase'''.
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| == References ==
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| {{reflist}}
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| == External links ==
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| * {{MeshName|Hydroxymethylglutaryl-CoA+reductase}}
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| [[Category:EC 1.1.1]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of known structure]]
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| {{1.1.1-enzyme-stub}}
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Revision as of 02:41, 25 February 2014
They contact me Emilia. It's not a common thing but what she likes doing is foundation jumping and now she is trying to make money with it. His family members lives in South Dakota but his spouse wants them to transfer. My day job is a meter reader.
Feel free to visit my blog; chatbook.biz