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| {{Infobox enzyme
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| | Name = Ribonucleoside-triphosphate reductase
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| | EC_number = 1.17.4.2
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| | CAS_number = 9068-66-0
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| | IUBMB_EC_number = 1/17/4/2
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| '''Ribonucleoside-triphosphate reductase''' ({{EC number|1.17.4.2}}, ''[[ribonucleotide reductase]]'', ''2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase'') is an [[enzyme]] with system name ''2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase''.<ref>{{cite journal | title = Cobamides and ribonucleotide reduction. I. Cobamide stimulation of ribonucleotide reduction in extracts of <em>Lactobacillus leichmannii</em> |author = Blakley, R.L. |journal = J. Biol. Chem. |year = 1965 |volume = 240 |pages = 2173–2180 |pmid = 14299643}}</ref><ref>{{cite journal | title = Purification and properties of cobamide-dependent ribonucleotide reductase from <em>Lactobacillus leichmannii</em> |author = Goulian, M. and Beck, W.S. |journal = J. Biol. Chem. |year = 1966 |volume = 241 |pages = 4233–4242 |pmid = 5924645}}</ref><ref>{{cite journal | title = The ribonucleotide reductases - a unique group of metalloenzymes essential for cell-proliferation |author = Lammers, M. and Follmann, H. |journal = Struct. Bonding |year = 1983 |volume = 54 |pages = 27–91 |pmid = }}</ref> This enzyme [[catalysis|catalyses]] the following [[chemical reaction]]
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| : 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H<sub>2</sub>O <math>\rightleftharpoons</math> ribonucleoside triphosphate + thioredoxin | |
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| Ribonucleoside-triphosphate reductase requires a cobamide coenzyme and ATP.
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| == References == | |
| {{reflist}}
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| == External links ==
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| * {{MeshName|Ribonucleoside-triphosphate+reductase}}
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| [[Category:EC 1.17.4]]
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Latest revision as of 13:14, 29 September 2014
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