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| {{enzyme
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| | Name = 3-(imidazol-5-yl)lactate dehydrogenase
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| | EC_number = 1.1.1.111
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| | CAS_number = 37250-42-3
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| | IUBMB_EC_number = 1/1/1/111
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| | GO_code = 0019155
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| In [[enzymology]], a '''3-(imidazol-5-yl)lactate dehydrogenase''' ({{EC number|1.1.1.111}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
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| :(S)-3-(imidazol-5-yl)lactate + NAD(P)+ <math>\rightleftharpoons</math> 3-(imidazol-5-yl)pyruvate + NAD(P)H + H<sup>+</sup>
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| The 3 [[substrate (biochemistry)|substrates]] of this enzyme are [[(S)-3-(imidazol-5-yl)lactate]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], and [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], whereas its 4 [[product (chemistry)|products]] are [[3-(imidazol-5-yl)pyruvate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], and [[hydrogen ion|H<sup>+</sup>]].
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| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on the CH-OH group of donor with NAD<sup>+</sup> or NADP<sup>+</sup> as acceptor. The systematic name of this enzyme class is '''(S)-3-(imidazol-5-yl)lactate:NAD(P)<sup>+</sup> oxidoreductase'''. This enzyme is also called '''imidazol-5-yl lactate dehydrogenase'''.
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| ==References==
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| {{reflist|1}}
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| * {{cite journal | author = Coote JG, Hassall H | year = 1969 | title = The role of imidazol-5-yl-lactate-nicotinamide-adenine dinucleotide phosphate oxidoreductase and histidine-2-oxoglutarate aminotransferase in the degradation of imidazol-5-yl-lactate by ''Pseudomonas acidovorans'' | journal = Biochem. J. | volume = 111 | pages = 237–9 | pmid = 4303364 | issue = 2 | pmc = 1187811 }}
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| * {{cite journal | author = Cortese R, Brevet J, Hedegaard J, Roche J | year = 1968 | title = [Identification and purification of an alpha-ketoacid aromatic reductase of ''Escherichia coli'' B] | language=French | journal = C. R. Seances. Soc. Biol. Fil. | volume = 162 | pages = 390–5 | pmid = 4237631 | issue = 2 }}
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| [[Category:EC 1.1.1]]
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| [[Category:NADPH-dependent enzymes]]
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| [[Category:NADH-dependent enzymes]]
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| [[Category:Enzymes of unknown structure]]
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| {{1.1.1-enzyme-stub}}
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