|
|
| Line 1: |
Line 1: |
| {{enzyme
| | Andera is what you can contact her but she by no means really liked that title. She is truly fond of caving but she doesn't have the time recently. I've always loved living in Kentucky but now I'm contemplating other choices. Credit authorising is how she makes a living.<br><br>Feel free to surf to my weblog :: love psychics ([http://si.dgmensa.org/xe/index.php?document_srl=48014&mid=c0102 find out here now]) |
| | Name = anthranilate 1,2-dioxygenase (deaminating, decarboxylating)
| |
| | EC_number = 1.14.12.1
| |
| | CAS_number = 9059-17-0
| |
| | IUBMB_EC_number = 1/14/12/1
| |
| | GO_code = 0018618
| |
| | image =
| |
| | width =
| |
| | caption =
| |
| }}
| |
| In [[enzymology]], an '''anthranilate 1,2-dioxygenase (deaminating, decarboxylating)''' ({{EC number|1.14.12.1}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
| |
| | |
| :anthranilate + NAD(P)H + 2 H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> catechol + CO<sub>2</sub> + NAD(P)+ + NH<sub>3</sub>
| |
| | |
| The 5 [[substrate (biochemistry)|substrates]] of this enzyme are [[anthranilate]], [[nicotinamide adenine dinucleotide|NADH]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 5 [[product (chemistry)|products]] are [[catechol]], [[carbon dioxide|CO<sub>2</sub>]], [[nicotinamide adenine dinucleotide|NAD<sup>+</sup>]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[ammonia|NH<sub>3</sub>]].
| |
| | |
| This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of two atoms o oxygen into the other donor. The systematic name of this enzyme class is '''anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)'''. Other names in common use include '''anthranilate hydroxylase''', '''anthranilic hydroxylase''', and '''anthranilic acid hydroxylase'''. This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[benzoate degradation via hydroxylation]], [[carbazole degradation]], and [[nitrogen metabolism]]. It employs one [[cofactor (biochemistry)|cofactor]], [[iron]].
| |
| | |
| ==References==
| |
| {{reflist|1}}
| |
| * {{cite journal | author = Kobayashi S and Hayaishi O | date = 1970 | title = Anthranilic acid conversion to catechol (Pseudomonas) | journal = Methods Enzymol. | volume = 17A | pages = 505–510 }}
| |
| * {{cite journal | author=Taniuchi H, Hatanaka M, Kuno S, Hayaishi O, Nakajima M, Kurihara N | date = 1964 | title = Enzymatic formation of catechol from anthranilic acid | journal = J. Biol. Chem. | volume = 239 | pages = 2204–2211 | pmid = 14209949 }}
| |
| | |
| {{1.14-enzyme-stub}}
| |
| | |
| [[Category:EC 1.14.12]]
| |
| [[Category:NADPH-dependent enzymes]]
| |
| [[Category:NADH-dependent enzymes]]
| |
| [[Category:Iron enzymes]]
| |
| [[Category:Enzymes of unknown structure]]
| |
| [[Category:Anthranilates]]
| |
Andera is what you can contact her but she by no means really liked that title. She is truly fond of caving but she doesn't have the time recently. I've always loved living in Kentucky but now I'm contemplating other choices. Credit authorising is how she makes a living.
Feel free to surf to my weblog :: love psychics (find out here now)