Protein design: Difference between revisions

From formulasearchengine
Jump to navigation Jump to search
en>Monkbot
 
en>Marianne.rooman
 
Line 1: Line 1:
In [[statistics]] a '''uniformly minimum-variance unbiased estimator''' or '''minimum-variance unbiased estimator (UMVUE''' or '''MVUE)''' is an unbiased estimator that has ''lower variance'' than ''any other'' unbiased estimator for ''all possible'' values of the parameter.
<br><br>When it comes to web hosting leaders, HostGator is [http://www.squidoo.com/search/results?q=plainly plainly] a leading tier option. We freely confess here at Internet Host Mentor, that HostGator places as a leading favorite within our team. Now HostGator didn't pay us to say that.<br>Now lets find out why<br><br>Dependability<br><br>Just like the various other hosting services we recommend, HostGator has a state of the art information center with backup power generators and all of the techno goodies to make her hum. HostGator also went a step further and introduced a Gigabit Uplink with a Guaranteed 20mbit connection. HostGator has likewise implemented a number of layers of network security ensuring the safety of all your information.<br><br>Rate<br><br>In in our book, when it concerns hosting, rate is a big deal. It is one of the crucial differentiators. Customers would like to know their hosting platform is reliable and has a lot of features and exceptional customer support, but they don't desire to pay an arm and a leg. In our viewpoint, to be successful in this extremely competitive field, you finest offer to your customers an attractive value proposition. That is not always the case. A few of the hosting companies struggle with successfully managing reliability, services/tools, customer relations, and cost. Nevertheless, HostGator is most likely the closest thing that you will find to pulling the rabbit out of the hat. For just $4.95 a month they provide a long list of features, devices, and services. Each hosting account comes geared up with well over 4,500 website design templates. HostGator is also well known for the outstanding unlimited diskspace and bandwidth they offer. They provide a very versatile and user friendly control board, endless sub domains, FTP accounts, and e-mail accounts and simply a laundry list of other features. Go take a look for yourself. Not to point out the $50 free of cost in Goggle AdWords credit. Let me be mindful right here so as not to let bias creep into my testimonial. These men offer a really durable value proposal when comparing everything that is essential to the webmaster. That is the conservative means of describing it.<br><br>Control Panel<br><br>HostGator makes use of a remarkably simple to navigate cPanel. The HostGator cPanel is among one of the most individual friendly complete showcased control panels. The fantastico feature has become everyone's preferred function. It allows web designers to install content management systems like WordPress and drupal, not to point out all the forums, blogs and websites that you can enable. Simply click their link below and you can really demo their cPanel in order to get "feel" for how it operates. Or try their complimentary SiteBuilder Tool as they have a trial for that.<br><br>Customer support<br><br>One of the reasons HostGator has actually been so effective is the reality that they offer quality client service. I know, it sounds like a damaged record, but it is what it is. All 5 of our suggested host stand out in this area and they much better as we consider this one of the review differentiators. HostGator provides honor winning support 24/7/365. They offer a 45 day money back guarantee. The gator team can be reached via email, phone or live chat. They want to solve any trouble that might aggravation you. Because a some of our web designers have an extensive body of experience with HostGator, we can talk to how excellent the customer care has been when we should reach out. They do not disappoint. HostGator's purpose it to address any internet hosting issue you have and offer suggestions that can save you a bunch of money and time. They also offer over 500+ Video Tutorials and 680+ Assist Articles. Yes, they have their act together.<br><br>Summary<br><br>Unlimited disk space<br>Unrestricted bandwidth<br>Unlimited domains<br>Immediate backups<br>99.9 uptime guarantee<br>WordPress friendly<br>45 day refund ensure<br>Free setup<br>24/7 support<br>$50 free Google AdWords<br>Website contractor<br><br>Conclusion<br><br>HostGator has shown it is one of the leaders in the internet hosting industry. HostGator offers top of the line client service and reliability. It is no mistake that HostGator is one of the fastest expanding business in America If you have any concerns regarding where by and how to use [http://www.offgridenergy.com.au/?option=com_k2&view=itemlist&task=user&id=58194 Hostgator Review], you can contact us at the internet site. .
 
For practical statistics problems, it is important to determine the UMVUE if one exists, since less-than-optimal procedures would naturally be avoided, other things being equal. This has led to substantial development of statistical theory related to the problem of optimal estimation. While the particular specification of "optimal" here &mdash; requiring [[unbiasedness]] and measuring "goodness" using the [[variance]] &mdash; may not always be what is wanted for any given practical situation, it is one where useful and generally applicable results can be found.
 
==Definition==
 
Consider estimation of <math>g(\theta)</math> based on data <math>X_1, X_2, \ldots, X_n</math> i.i.d. from some member of a family of densities <math> p_\theta, \theta \in \Omega</math>, where <math>\Omega</math> is the parameter space. An unbiased estimator <math>\delta(X_1, X_2, \ldots, X_n)</math> of <math> g(\theta) </math> is ''UMVUE'' if <math> \forall \theta \in \Omega</math>,
 
:<math> \mathrm{var}(\delta(X_1, X_2, \ldots, X_n)) \leq \mathrm{var}(\tilde{\delta}(X_1, X_2, \ldots, X_n)) </math>
 
for any other unbiased estimator <math> \tilde{\delta}. </math>
 
If an unbiased estimator of <math> g(\theta) </math> exists, then one can prove there is an essentially unique MVUE. Using the [[Rao–Blackwell theorem]] one can also prove that determining the MVUE is simply a matter of finding a [[complete statistic|complete]] [[sufficient statistic|sufficient]] statistic for the family <math>p_\theta, \theta \in \Omega </math> and conditioning ''any'' unbiased estimator on it.
 
Further, by the [[Lehmann–Scheffé theorem]], an unbiased estimator that is a function of a complete, sufficient statistic is the UMVUE estimator.
 
Put formally, suppose <math>\delta(X_1, X_2, \ldots, X_n)</math> is unbiased for <math>g(\theta)</math>, and that <math>T</math> is a complete sufficient statistic for the family of densities. Then
 
:<math> \eta(X_1, X_2, \ldots, X_n) = \mathrm{E}(\delta(X_1, X_2, \ldots, X_n)|T)\,</math>
 
is the MVUE for <math>g(\theta). </math>
 
A [[Bayesian statistics|Bayesian]] analog is a [[Bayes estimator]], particularly with [[minimum mean square error]] (MMSE).
 
==Estimator selection==
An [[efficient estimator]] need not exist, but if it does and if it is unbiased,
it is the MVUE. Since the [[mean squared error]] (MSE) of an estimator ''δ'' is
 
:<math> \operatorname{MSE}(\delta) = \mathrm{var}(\delta) +[ \mathrm{bias}(\delta)]^{2}\ </math>
 
the MVUE minimizes MSE ''among unbiased estimators''. In some cases biased estimators have lower MSE because they have a smaller variance than does any unbiased estimator; see [[estimator bias]].
 
==Example==
Consider the data to be a single observation from an [[Absolutely continuous random variable|absolutely continuous distribution]] on <math>\mathbb{R} </math>
with density
 
:<math> p_\theta(x) = \frac{ \theta e^{-x} }{(1 + e^{-x})^{\theta + 1} } </math>
 
and we wish to find the UMVU estimator of  
 
:<math> g(\theta) = \frac{1}{\theta^{2}} </math>
 
First we recognize that the density can be written as
 
:<math> \frac{ e^{-x} } { 1 + e^{-x} } \exp( -\theta \log(1 + e^{-x}) + \log(\theta)) </math>
 
Which is an exponential family with sufficient statistic <math>T = \mathrm{log}(1 + e^{-x})</math>. In
fact this is a full rank exponential family, and therefore <math> T </math> is complete sufficient. See [[exponential family]]
for a derivation which shows
 
: <math> \mathrm{E}(T) = -\frac{1}{\theta},\quad \mathrm{var}(T) = \frac{1}{\theta^{2}} </math>
 
Therefore
 
:<math> \mathrm{E}(T^2) = \frac{2}{\theta^{2}} </math>
 
Clearly <math> \delta(X) = \frac{T^2}{2} </math> is unbiased, thus the UMVU estimator is
 
:<math> \eta(X) = \mathrm{E}(\delta(X) | T) = \mathrm{E} \left( \left. \frac{T^2}{2} \,\right|\, T \right) = \frac{T^{2}}{2} = \frac{\log(1 + e^{-X})^{2}}{2}</math>  
 
This example illustrates that an unbiased function of the complete sufficient statistic will be UMVU.
 
== Other examples ==
* For a normal distribution with unknown mean and variance, the [[sample mean]] and (unbiased) [[sample variance]] are the MVUEs for the population mean and population variance.
*:However, the [[sample standard deviation]] is not unbiased for the population standard deviation – see [[unbiased estimation of standard deviation]].
*:Further, for other distributions the sample mean and sample variance are not in general MVUEs – for a [[Uniform distribution (continuous)|uniform distribution]] with unknown upper and lower bounds, the [[mid-range]] is the MVUE for the population mean.
* If ''k'' exemplars are chosen (without replacement) from a [[discrete uniform distribution]] over the set {1,&nbsp;2,&nbsp;...,&nbsp;''N''} with unknown upper bound ''N'', the MVUE for ''N'' is
:: <math>\frac{k+1}{k} m - 1,</math>
:where ''m'' is the [[sample maximum]]. This is a scaled and shifted (so unbiased) transform of the sample maximum, which is a sufficient and complete statistic. See [[German tank problem]] for details.
 
== See also ==
* [[Best linear unbiased estimator]] (BLUE)
* [[Lehmann–Scheffé theorem]]
* [[U-statistic]]
 
=== Bayesian analogs ===
* [[Bayes estimator]]
* [[Minimum mean square error]] (MMSE)
 
== References ==
* {{cite book
  | last = Keener
  | first = Robert W.
  | title = Statistical Theory: Notes for a Course in Theoretical Statistics
  | publisher = Springer
  | date = 2006
  | pages = 47–48, 57–58 }}
* {{cite book
  | last = Voinov V. G.,
  | first = Nikulin M.S.
  | title = Unbiased estimators and their applications, Vol.1: Univariate case
  | publisher = Kluwer Academic Publishers
  | date = 1993
  | pages = 521p }}
 
[[Category:Estimation theory]]

Latest revision as of 14:09, 5 January 2015



When it comes to web hosting leaders, HostGator is plainly a leading tier option. We freely confess here at Internet Host Mentor, that HostGator places as a leading favorite within our team. Now HostGator didn't pay us to say that.
Now lets find out why

Dependability

Just like the various other hosting services we recommend, HostGator has a state of the art information center with backup power generators and all of the techno goodies to make her hum. HostGator also went a step further and introduced a Gigabit Uplink with a Guaranteed 20mbit connection. HostGator has likewise implemented a number of layers of network security ensuring the safety of all your information.

Rate

In in our book, when it concerns hosting, rate is a big deal. It is one of the crucial differentiators. Customers would like to know their hosting platform is reliable and has a lot of features and exceptional customer support, but they don't desire to pay an arm and a leg. In our viewpoint, to be successful in this extremely competitive field, you finest offer to your customers an attractive value proposition. That is not always the case. A few of the hosting companies struggle with successfully managing reliability, services/tools, customer relations, and cost. Nevertheless, HostGator is most likely the closest thing that you will find to pulling the rabbit out of the hat. For just $4.95 a month they provide a long list of features, devices, and services. Each hosting account comes geared up with well over 4,500 website design templates. HostGator is also well known for the outstanding unlimited diskspace and bandwidth they offer. They provide a very versatile and user friendly control board, endless sub domains, FTP accounts, and e-mail accounts and simply a laundry list of other features. Go take a look for yourself. Not to point out the $50 free of cost in Goggle AdWords credit. Let me be mindful right here so as not to let bias creep into my testimonial. These men offer a really durable value proposal when comparing everything that is essential to the webmaster. That is the conservative means of describing it.

Control Panel

HostGator makes use of a remarkably simple to navigate cPanel. The HostGator cPanel is among one of the most individual friendly complete showcased control panels. The fantastico feature has become everyone's preferred function. It allows web designers to install content management systems like WordPress and drupal, not to point out all the forums, blogs and websites that you can enable. Simply click their link below and you can really demo their cPanel in order to get "feel" for how it operates. Or try their complimentary SiteBuilder Tool as they have a trial for that.

Customer support

One of the reasons HostGator has actually been so effective is the reality that they offer quality client service. I know, it sounds like a damaged record, but it is what it is. All 5 of our suggested host stand out in this area and they much better as we consider this one of the review differentiators. HostGator provides honor winning support 24/7/365. They offer a 45 day money back guarantee. The gator team can be reached via email, phone or live chat. They want to solve any trouble that might aggravation you. Because a some of our web designers have an extensive body of experience with HostGator, we can talk to how excellent the customer care has been when we should reach out. They do not disappoint. HostGator's purpose it to address any internet hosting issue you have and offer suggestions that can save you a bunch of money and time. They also offer over 500+ Video Tutorials and 680+ Assist Articles. Yes, they have their act together.

Summary

Unlimited disk space
Unrestricted bandwidth
Unlimited domains
Immediate backups
99.9 uptime guarantee
WordPress friendly
45 day refund ensure
Free setup
24/7 support
$50 free Google AdWords
Website contractor

Conclusion

HostGator has shown it is one of the leaders in the internet hosting industry. HostGator offers top of the line client service and reliability. It is no mistake that HostGator is one of the fastest expanding business in America If you have any concerns regarding where by and how to use Hostgator Review, you can contact us at the internet site. .