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{{enzyme
| Name = 1-phosphatidylinositol-5-phosphate 4-kinase
| EC_number = 2.7.1.149
| CAS_number =
| IUBMB_EC_number = 2/7/1/149
| GO_code = 0016309
| image =
| width =
| caption =
}}
In [[enzymology]], a '''1-phosphatidylinositol-5-phosphate 4-kinase''' ({{EC number|2.7.1.149}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]
 
:ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate <math>\rightleftharpoons</math> ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
 
Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[adenosine triphosphate|ATP]] and [[1-phosphatidyl-1D-myo-inositol 5-phosphate]], whereas its two [[product (chemistry)|products]] are [[adenosine diphosphate|ADP]] and [[1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate]].
 
This enzyme belongs to the family of [[transferase]]s, specifically those transferring phosphorus-containing groups ([[phosphotransferase]]s) with an alcohol group as acceptor. The systematic name of this enzyme class is '''ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase'''. This enzyme is also called '''type II PIP kinase'''. This enzyme participates in 3 [[metabolism|metabolic pathways]]: [[inositol phosphate metabolism]], [[phosphatidylinositol signaling system]], and [[regulation of actin cytoskeleton]].
 
==References==
{{reflist|1}}
* {{cite journal | author = Rameh LE, Tolias KF, Duckworth BC, Cantley LC | date = 1997 | title = A new pathway for synthesis of phosphatidylinositol-4,5-bisphosphate | journal = Nature. | volume = 390 | pages = 192&ndash;6  | pmid = 9367159 | doi = 10.1038/36621 | issue = 6656 }}
 
{{enzyme-stub}}
 
[[Category:EC 2.7.1]]
[[Category:Enzymes of unknown structure]]

Revision as of 10:23, 1 June 2013

Template:Enzyme In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (Air Transportation Experts Kull from Wingham, has many interests that include butterflies, property developers in singapore and digital photography. Is a travel freak and in recent past made buy a house in singapore journey to Paleochristian and Byzantine Monuments of Thessalonika.) is an enzyme that catalyzes the chemical reaction

ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate

Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 5-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton.

References

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