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{{enzyme
This is a preview for the new '''MathML rendering mode''' (with SVG fallback), which is availble in production for registered users.
| Name = sirohydrochlorin ferrochelatase
| EC_number = 4.99.1.4
| CAS_number =
| IUBMB_EC_number = 4/99/1/4
| GO_code = 0051266
| image =
| width =
| caption =
}}
[[Image:Siroheme.svg|thumb|Structure of siroheme]]
In [[enzymology]], a '''sirohydrochlorin ferrochelatase''' ({{EC number|4.99.1.4}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]


:sirohydrochlorin + Fe<sup>2+</sup> <math>\rightleftharpoons</math> siroheme + 2H<sup>+</sup>
If you would like use the '''MathML''' rendering mode, you need a wikipedia user account that can be registered here [[https://en.wikipedia.org/wiki/Special:UserLogin/signup]]
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Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[sirohydrochlorin]] and [[Ferrous ion|Fe2<sup>+</sup>]], whereas its two [[product (chemistry)|products]] are [[sirohaem]] and [[proton|H<sup>+</sup>]].
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This enzyme belongs to the family of [[lyase]]s, to be specific the "catch-all" class of lyases that do not fit into any other sub-class.  The systematic name of this enzyme class is '''siroheme ferro-lyase (sirohydrochlorin-forming)'''. The enzyme is also known as SirB and present in all plants and nitrate and sulfate assimilating/dissimilating bacteria.  Siroheme is a co-factor of both assimilatory and dissimilatory nitrite and sulfite reductases. Siroheme is synthesized from the central tetrapyrrole molecule uroporphyrinogen III, which forms the first branch-point of tetrapyrrole biosynthetic pathway, the other branch being the heme/chlorophyll branch. The siroheme branch consists of three steps, methylation, dehydrogenation and ferrochelation, with the last step carried out by sirohydrochlorin ferrochelatase.
'''MathML'''
:<math forcemathmode="mathml">E=mc^2</math>


Sirohydrochlorin ferrochelatase is a class II chelatase i.e. it does not require ATP for its activity unlike class I chelatases such as [[Magnesium chelatase|Mg-chelatase]]. In ''E. coli'', all three steps of siroheme biosynthesis are carried out by a single multifunctional enzyme called CysG, while in yeast [[Baker's yeast|''Saccharomyces cerevisiae'']] the last two steps are carried out by a bifunctional enzyme called Met8p. CysG and Met8p share common folds but are unrelated to SirB and constitute the so-called class III chelatase. SirB belongs to CbiX family protein and the plant SirB is half the length of bacterial SirB and aligns with its N- and C-terminal halves suggesting that the longer form evolved from the gene duplication and fusion of the shorter form.
<!--'''PNG''' (currently default in production)
:<math forcemathmode="png">E=mc^2</math>


Sirohydrochlorin ferrochelatase from all [[land plants]] and certain [[green algae]] but not [[bacteria]] or other algae consists of an [[iron sulfur cluster]], which can switch between [2Fe-2S] and [4Fe-4S] forms depending on the redox status of the cellular milieu. Although it is not clearly determined what role this switching of the cluster might play, it is postulated to be involved in a critical redox regulation of siroheme biosynthesis.
'''source'''
:<math forcemathmode="source">E=mc^2</math> -->


==References==
<span style="color: red">Follow this [https://en.wikipedia.org/wiki/Special:Preferences#mw-prefsection-rendering link] to change your Math rendering settings.</span> You can also add a [https://en.wikipedia.org/wiki/Special:Preferences#mw-prefsection-rendering-skin Custom CSS] to force the MathML/SVG rendering or select different font families. See [https://www.mediawiki.org/wiki/Extension:Math#CSS_for_the_MathML_with_SVG_fallback_mode these examples].
{{reflist|1}}
* {{cite journal | author = Saha K, Webb ME, Rigby SEJ, Leech HK, Warren MJ, Smith AG | year = 2012 | title = Characterization of the evolutionarily conserved iron–sulfur cluster of sirohydrochlorin ferrochelatase from Arabidopsis thaliana | journal = Biochem J. | volume = 444 | pages = 227&ndash;237  | pmid =  22414210 | doi = 10.1042/BJ20111993 | issue = 2 }}
* {{cite journal | author = Warren MJ | year = 2002 | title = The structure of Saccharomyces cerevisiae Met8p, a bifunctional dehydrogenase and ferrochelatase | journal = EMBO J. | volume = 21 | pages = 2068&ndash;75  | pmid = 11980703 | doi = 10.1093/emboj/21.9.2068 | last2 = Raux | first2 = E | last3 = Brindley | first3 = AA | last4 = Leech | first4 = HK | last5 = Wilson | first5 = KS | last6 = Hill | first6 = CP | last7 = Warren | first7 = MJ | issue = 9 | pmc = 125995 }}
* {{cite journal | author = Warren MJ, Raux E, Schubert HL, Escalante-Semerena JC | year = 2002 | title = The biosynthesis of adenosylcobalamin (vitamin B12) | journal = Nat. Prod. Rep. | volume = 19 | pages = 390&ndash;412  | pmid = 12195810 | doi = 10.1039/b108967f | issue = 4 }}


[[Category:EC 4.99.1]]
==Demos==
[[Category:Enzymes of unknown structure]]


Here are some [https://commons.wikimedia.org/w/index.php?title=Special:ListFiles/Frederic.wang demos]:


{{enzyme-stub}}
 
* accessibility:
** Safari + VoiceOver: [https://commons.wikimedia.org/wiki/File:VoiceOver-Mac-Safari.ogv video only], [[File:Voiceover-mathml-example-1.wav|thumb|Voiceover-mathml-example-1]], [[File:Voiceover-mathml-example-2.wav|thumb|Voiceover-mathml-example-2]], [[File:Voiceover-mathml-example-3.wav|thumb|Voiceover-mathml-example-3]], [[File:Voiceover-mathml-example-4.wav|thumb|Voiceover-mathml-example-4]], [[File:Voiceover-mathml-example-5.wav|thumb|Voiceover-mathml-example-5]], [[File:Voiceover-mathml-example-6.wav|thumb|Voiceover-mathml-example-6]], [[File:Voiceover-mathml-example-7.wav|thumb|Voiceover-mathml-example-7]]
** [https://commons.wikimedia.org/wiki/File:MathPlayer-Audio-Windows7-InternetExplorer.ogg Internet Explorer + MathPlayer (audio)]
** [https://commons.wikimedia.org/wiki/File:MathPlayer-SynchronizedHighlighting-WIndows7-InternetExplorer.png Internet Explorer + MathPlayer (synchronized highlighting)]
** [https://commons.wikimedia.org/wiki/File:MathPlayer-Braille-Windows7-InternetExplorer.png Internet Explorer + MathPlayer (braille)]
** NVDA+MathPlayer: [[File:Nvda-mathml-example-1.wav|thumb|Nvda-mathml-example-1]], [[File:Nvda-mathml-example-2.wav|thumb|Nvda-mathml-example-2]], [[File:Nvda-mathml-example-3.wav|thumb|Nvda-mathml-example-3]], [[File:Nvda-mathml-example-4.wav|thumb|Nvda-mathml-example-4]], [[File:Nvda-mathml-example-5.wav|thumb|Nvda-mathml-example-5]], [[File:Nvda-mathml-example-6.wav|thumb|Nvda-mathml-example-6]], [[File:Nvda-mathml-example-7.wav|thumb|Nvda-mathml-example-7]].
** Orca: There is ongoing work, but no support at all at the moment [[File:Orca-mathml-example-1.wav|thumb|Orca-mathml-example-1]], [[File:Orca-mathml-example-2.wav|thumb|Orca-mathml-example-2]], [[File:Orca-mathml-example-3.wav|thumb|Orca-mathml-example-3]], [[File:Orca-mathml-example-4.wav|thumb|Orca-mathml-example-4]], [[File:Orca-mathml-example-5.wav|thumb|Orca-mathml-example-5]], [[File:Orca-mathml-example-6.wav|thumb|Orca-mathml-example-6]], [[File:Orca-mathml-example-7.wav|thumb|Orca-mathml-example-7]].
** From our testing, ChromeVox and JAWS are not able to read the formulas generated by the MathML mode.
 
==Test pages ==
 
To test the '''MathML''', '''PNG''', and '''source''' rendering modes, please go to one of the following test pages:
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==Bug reporting==
If you find any bugs, please report them at [https://bugzilla.wikimedia.org/enter_bug.cgi?product=MediaWiki%20extensions&component=Math&version=master&short_desc=Math-preview%20rendering%20problem Bugzilla], or write an email to math_bugs (at) ckurs (dot) de .

Latest revision as of 22:52, 15 September 2019

This is a preview for the new MathML rendering mode (with SVG fallback), which is availble in production for registered users.

If you would like use the MathML rendering mode, you need a wikipedia user account that can be registered here [[1]]

  • Only registered users will be able to execute this rendering mode.
  • Note: you need not enter a email address (nor any other private information). Please do not use a password that you use elsewhere.

Registered users will be able to choose between the following three rendering modes:

MathML

E=mc2


Follow this link to change your Math rendering settings. You can also add a Custom CSS to force the MathML/SVG rendering or select different font families. See these examples.

Demos

Here are some demos:


Test pages

To test the MathML, PNG, and source rendering modes, please go to one of the following test pages:

Bug reporting

If you find any bugs, please report them at Bugzilla, or write an email to math_bugs (at) ckurs (dot) de .

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